| Project/Area Number |
21791095
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Keio University |
|---|
Principal Investigator |
KAWASAKI Hiroshi Keio University, 医学部, 研究員(非常勤) (70445344)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 皮膚バリア / アトピー性皮膚炎 / フィラグリン |
|---|
| Research Abstract |
To better understand the functional properties of filaggrin and to develop a new model for elucidating the pathogenesis of atopic dermatitis, flaky tail mice, which have mutant filaggrin and its expression is significantly reduced, were utilized. This study exhibited enhanced outside-to-inside permeability in flaky tail mice, however it indicated filaggrin deficiency itself was not affected with increased transepidermal water loss. Flaky tail mice showed enhanced percutaneous immune response, as compared with wild-type mice.
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