The analysis of the activated mechanism of transcription factor Sp1 in the keratinization mechanism that aimed at the new treatment.
| Project/Area Number |
21791098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Juntendo University |
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Principal Investigator |
TAKAGI Atsushi Juntendo University, 医学部, 准教授 (40459160)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Sp1 / Sp3 / 角化機序 / 角化関連遺伝 / 角化関連遺伝子 / SiRNA |
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| Research Abstract |
We paid attention to transcription factor Sp1 to elucidate a keratinization of the skin mechanism and examined effect on manifestation of the keratinization-related gene of the transcription factor such as Sp1/Sp3. As a result, Sp1 and Sp3 were associated with keratinization-related gene manifestation via multiple pathways, and it was suggested that Sp1 and Sp3 played a different role depending on an individual gene.
In the ATP2A2 gene which was a keratinization-related gene, the results of UVB-treatment experiments suggested a possibility that COX-2 inhibition restores UVB-mediated down regulation of ATP2A2 expression.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients2010
Author(s)
Niwa Y, Potaczek DP, Kanada S, Takagi A, Shimokawa N, Ito T, Mitsuishi K, Okubo Y, Tajima M, Hobo A, Ng W, Tsuboi R, Ikeda S, Ogawa H, Okumura K, Nishiyama C
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Journal Title
Int J Immnunogenet. 37
Pages: 139-141
Related Report
Peer Reviewed
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