| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We paid attention to transcription factor Sp1 to elucidate a keratinization of the skin mechanism and examined effect on manifestation of the keratinization-related gene of the transcription factor such as Sp1/Sp3. As a result, Sp1 and Sp3 were associated with keratinization-related gene manifestation via multiple pathways, and it was suggested that Sp1 and Sp3 played a different role depending on an individual gene.
In the ATP2A2 gene which was a keratinization-related gene, the results of UVB-treatment experiments suggested a possibility that COX-2 inhibition restores UVB-mediated down regulation of ATP2A2 expression.
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