Association between γδT cells abnormalities and pathogensis in sarcoidosis.

Research Project

Project/Area Number	21791102
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Dermatology
Research Institution	Kansai Medical University
Principal Investigator	UEDA Ikuko Kansai Medical University, 医学部, 助教 (80452100)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	皮膚生理学 / サルコイドーシス / γδT細胞
Research Abstract	No significant differences in the absolute number of γδ T cells and the proportion of γδ T cells, and cell surface expression of CD62L and CD69 were observed in sarcoidosis patients. Abnormality of γδ T cells repertoire were observed ; the frequency of Vγ2+ cells was decreased and the frequency of Vγ9+ cells were increased in sarcoidosis patients compared to control. After the stimulation PMA plus ionomycin, γδ T cells from some patients have increased production of IFN-γ. It was confirmed that IFN-γ induced the proliferation of monocyte. γδ T cells may related to the pathogenesis of sarcoidosis by abnormal production of IFN-γ.