| Project/Area Number |
21791103
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | Kinki University |
|---|
Principal Investigator |
NAKAYAMA Takashi Kinki University, 医学部, 講師 (60319663)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 癌 / 皮膚T細胞リンパ腫 / Fra-2 / AP-1 / c-Myb / ケモカイン / ケモカイン受容体 / 発癌 |
|---|
| Research Abstract |
In this study, we showed that Fra-2 and c-Myb were consistently co-expressed in cutaneous T-cell lymphomas (CTCLs), and contributed to cell proliferation. Furthermore, we showed that c-Myb was a direct target gene of Fra-2 in CTCLs. In addition, we identified that RASGRP2 was a c-Myb target gene and contributed to cell proliferation in CTCLs. Taken together, our findings support the notion that the Fra-2-c-Myb oncogenic pathway plays a major role in the oncogenesis of CTCLs.
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