Investigation on the mechanism underlying suppression of contact hypersensitivity in UVB irradiated skin.

• Project/Area Number: 21791104
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: YOSHIKI Ryutaro University of Occupational and Environmental Health, Japan, 医学部, 助教 (30412646)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 紫外線 / 免疫抑制 / 皮膚樹状細胞 / 調節性T細胞 / インターロイキン10 / OX40リガンド / RANKL / ケラチノサイト / OX40 / 角化細胞

Research Abstract

The underlying mechanism of local immunosuppression by ultraviolet ray irradiation has not been fully elucidated so far. In this study, we discovered that OX40 ligand and interleukin-10 producing Langerhans cells play a crucial role in inducing antigen-specific regulatory T cells.

Research Products

• [Journal Article] The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression (2010)
  • Author(s): R Yoshiki, K Kabashima, JI Sakabe, K Sugita, T Bito, M Nakamura, B Malissen, Y Tokura
  • Journal Title: Journal of Immunology 184 Pages: 5670-5677
  • Peer Reviewed
• [Journal Article] The mandatory role of IL-10-producing and OX40 ligand-expressing mature Langerhans cells in local UVB-induced immunosuppression. (2010)
  • Author(s): Ryutaro Yoshiki, Kenji Kabashima, Jun-ichi Sakabe, Kazunari Sugita, Toshinori Bito, Motonobu Nakamura, Bernard Malissen, Yoshiki Tokura
  • Journal Title: Journal of Immunology Volume: 184 Pages: 5670-5677
  • Peer Reviewed
• [Presentation] Local UVB-induced immunosuppression is mediated by IL-10 producing and OX40L-positive mature Langerhans cells. (2010)
  • Author(s): Ryutaro Yoshiki
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸(神戸ポートピアホテル、神戸国際展示場)
  • Year and Date: 2010-08-26
• [Presentation] Local UVB-induced immunosuppression is mediated by IL-10 producing and OX40L-positive mature Langerhans cells. (2010)
  • Author(s): Ryutaro Yoshiki, Kenji Kabashima, Jun-ichi Sakabe, Kazunari Sugita, Toshinori Bito, Motonobu Nakamura, Yoshiki Tokura.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-24
• [Presentation] Local UVB-induced immunosuppression is mediated by IL-10-producing and OX40L-positive mature Langerhans cells. (2009)
  • Author(s): Ryutaro Yoshiki, Kenji Kabashima, Jun-ichi Sakabe, Kazunari Sugita, Toshinori Bito, Motonobu Nakamura, Yoshiki Tokura
  • Organizer: 第34回日本研究皮膚科学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2009-12-04
• [Presentation] Local UVB-induced immunosuppression is mediated by IL-10-producing and OX40L-positive mature Langerhans cells (2009)
  • Author(s): 吉木竜太郎
  • Organizer: European Society of Dermatological Research
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2009-09-11
• [Presentation] Local UVB-induced immunosuppression is mediated by IL-10-producing and OX40L-positive mature Langerhans cells. (2009)
  • Author(s): Ryutaro Yoshiki, Kenji Kabashima, Jun-ichi Sakabe, Kazunari Sugita, Toshinori Bito, Motonobu Nakamura, Yoshiki Tokura
  • Organizer: 39^<th> European Society of Dermatological Research
  • Place of Presentation: ブタペスト、ハンガリー
  • Year and Date: 2009-09-10
• [Presentation] UVB照射時における皮膚樹状細胞の機能変化 (2009)
  • Author(s): 吉木竜太郎
  • Organizer: 第31回 日本光医学・光生物学会
  • Place of Presentation: 梅田スカイビル(大阪府)
  • Year and Date: 2009-07-25
• [Presentation] UVB照射時における皮膚樹状細胞の機能変化 (2009)
  • Author(s): 吉木竜太郎、椛島健治、坂部純一、杉田和成、尾藤利憲、中村元信、戸倉新樹
  • Organizer: 第31回光医学光生物学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-24