| Project/Area Number |
21791115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
ENDO Taro Niigata University, 医歯学系, 助教 (70515759)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自閉症スペクトラム障害 / MRI / MRS / セロトニン・トランスポーター遺伝子 / セロトニン1A受容体遺伝子 / セロトニン2A受容体遺伝子 / 自閉症 / アスペルガー障害 / セロトニン受容体遺伝子 / トリプトファン水酸化酵素2遺伝子 |
|---|
| Research Abstract |
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, the diagnostic biological markers for ASD have not been established. We examined the relationships between the serotonin-related genes and the intermediate phenotypes of ASD (brain morphology, chemical metabolites, and clinical symptoms). Our findings revealed that follows ; 1) Individuals with ASD had neurodevelopmental disturbance in the medial temporal lobes, and the degree of this disturbance varies between ASD subtypes and contributes to the severity ; 2) Individuals with ASD have smaller thalamus and the small thalamus is related to the clinical symptoms of Relating to People ; 3) The polymorphisms of 5-HTTLPR and 5-HTRIA gene are related to a number of clinical symptoms of ASD ; The polymorphism of 5-HTTLPR gene influences the neural development of the medial prefrontal cortex among individuals with ASD. These intermediate phenotypes affected by serotonin-related genes are considered a potential biological marker for ASD.
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