| Project/Area Number |
21791116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Niigata University |
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Principal Investigator |
KANEKO Naoshi Niigata University, 医歯学総合病院, 講師 (40515657)
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| Research Collaborator |
WATANABE Yuichiro 新潟大学, 保健管理本部, 講師 (90401744)
NUNOKAWA Ayako 新潟大学, 医歯学総合病院, 助教 (90584607)
SOMEYA Toshiyuki 新潟大学, 医歯学系, 教授 (50187902)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 臨床精神分子遺伝学 / コピー数多型 / 統合失調症 / 関連解析 / SNP / 分子遺伝 / 連鎖解析 |
|---|
| Research Abstract |
We conducted a genome-wide copy number variation (CNV) screening in a large multiplex schizophrenia pedigree and performed a follow up case-control study. In screening using microarray method, we found a CNV which potentially co-segregated with schizophrenia. We analyzed This CNV by means of a TaqMan real-time PCR assay and found complete deletions of CNVs in five of six affected individuals and an individual with affection status of unknown. We also conducted a case-control study in 627 patients of schizophrenia and 620 healthy controls. There was no significant association between complete deletions of the CNVs and schizophrenia. Taken together, these results suggest that the CNV may not confer increased susceptibility to schizophrenia.
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