A research of aberrant brain volume and function and biological marker in patients with autism spectrum disorders.

• Project/Area Number: 21791120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: University of Fukui
• Principal Investigator: KOSAKA Hirotaka 福井大学, 子どものこころの発達研究センター, 特命准教授 (70401966)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 児童・思春期精神医学 / 自閉症スペクトラム障害 / voxel based morphometry (VBM) / functional MRI (fMRI) / オキシトシン / 社会性の障害 / 右島 / 右下前頭回 / 児童思春期精神医学 / 広汎性発達障害(PDD) / 共同注視 / アイコンタクト / コミュニケーション / 自己顔認知 / 右下前頭葉 / 右側島 / 広汎性発達障害(Pervasive Developmental Disorders ; PDD) / 自閉症(自閉性障害) / アスペルガー障害 / Voxel Based Morphometry (VBM) / Diffusion tensor imaging (DTI) / 血液検査

Research Abstract

Much evidence indicates that patients with autism spectrum disorders (ASD) demonstrate marked social dysfunction. However,the etiology is still unknown. We have studied social dysfunctions in youth with high-functioning ASD compared with typically developing participants using voxel-based morphometry and functional MRI. These aberrant neuroimaging findings could be social brain marker in ASD. Next, I reported oxytocin effect to a patient with ASD

Research Products

• [Journal Article] 自閉症スペクトラム障害のfMRI研究 (2013)
  • Author(s): 小坂浩隆、等
  • Journal Title: 脳 Volume: 21 16(2) Pages: 45-51
• [Journal Article] 自閉症スペクトラム障害の社会性障害を探る: fMRI 研究 (2013)
  • Author(s): 小坂浩隆、等
  • Journal Title: 日本生物学的精神医学会誌 Volume: 23(4) Pages: 255-61
  • NAID: 130005395482
  • Peer Reviewed
• [Journal Article] 自閉症スペクトラム障害のfMRI研究 ＜総説＞ (2013)
  • Author(s): 小坂 浩隆 等
  • Journal Title: 脳21 Volume: 16(2) Pages: 45-51
  • Peer Reviewed
• [Journal Article] Emotional responses associated with self-face processing in individuals with autism spectrum disorders: An fMRI study (2012)
  • Author(s): Morita T, Kosaka H, et al.
  • Journal Title: Social Neuroscience Volume: 7(3-4) Pages: 223-239
  • Peer Reviewed
• [Journal Article] Long-term oxytocin administration improves social behaviors in a girl with autistic disorder. (2012)
  • Author(s): Kosaka H, et al.
  • Journal Title: BMC Psychiatry Volume: 12(1) Pages: 110-110
  • Peer Reviewed
• [Journal Article] Hard to "tune in": neural mechanisms of live face-to-face interaction in individuals with high-functioning autistic spectrum disorder. (2012)
  • Author(s): Tanabe HC, Kosaka H, et al.
  • Journal Title: Front Hum Neurosci Volume: 6 Pages: 268-268
  • Peer Reviewed
• [Journal Article] Switching to aripiprazole in subjects with pervasive developmental disorders showing tolerability issues with risperidone. (2012)
  • Author(s): Ishitobi M et al.,
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 37(1) Issue: 1 Pages: 128-131
  • DOI: 10.1016/j.pnpbp.2011.12.015
  • Peer Reviewed
• [Journal Article] Emotional responses associated with self-face processing in individuals with autism spectrum disorders : An fMRI study (2012)
  • Author(s): Morita, T., Kosaka, H., Saito, D., Ishitobi, M., Munesue, T., Itakura, S., et al
  • Journal Title: Social Neuroscience Volume: 7(3) Issue: 3 Pages: 223-239
  • DOI: 10.1080/17470919.2011.598945
  • Peer Reviewed
• [Journal Article] Long-term oxytocin administration improves social behaviors in a girl with autistic disorder (2012)
  • Author(s): Kosaka H et al.,
  • Journal Title: BMC Psychiatry Volume: 12(1) Issue: 1 Pages: 110-110
  • DOI: 10.1186/1471-244x-12-110
  • Peer Reviewed
• [Journal Article] Hard to "tune in" : neural mechanisms of live face-to-face interaction with high-functioning autistic spectrum disorder (2012)
  • Author(s): Tanabe HC, Kosaka H, Saito DN, Koike T, Hayashi MJ, Izuma K, Komeda H, Ishitobi M, Omori M, Munesue T, Okazawa H, Wada Y, Sadato N
  • Journal Title: Front Hum Neurosci Volume: 6 Pages: 268-268
  • DOI: 10.3389/fnhum.2012.00268
  • Peer Reviewed
• [Journal Article] 自閉症スペクトラム障害の社会性障害を探る: fMRI 研究 (2012)
  • Author(s): 小坂 浩隆 等
  • Journal Title: 日本生物学的精神医学会誌 Volume: 23（4） Pages: 255-261
  • NAID: 130005395482
  • Peer Reviewed
• [Journal Article] Differential amygdala response to lower face in patients with autistic spectrum disorders: an fMRI study (2011)
  • Author(s): Ishitobi M, Kosaka H, et al.
  • Journal Title: Research in Autism Spectrum Disorders Volume: 5 Pages: 910-9
  • Peer Reviewed
• [Journal Article] Differential amygdala response to lower face in patients with autistic spectrum disorders : an fMRI study (2011)
  • Author(s): Ishitobi M, Kosaka H, et al
  • Journal Title: Research in Autism Spectrum Disorders Volume: 5 Pages: 910-919
  • Peer Reviewed
• [Journal Article] Differential amygdala response to lower face in patients with autistic spectrum disorders : an fMRI study. (2011)
  • Author(s): Ishitobi M, Kosaka H, et al.
  • Journal Title: Research in Autism Spectrum Disorders Volume: 5 Pages: 910-919
  • Peer Reviewed
• [Journal Article] Smaller Insula and Inferior Frontal Volumes in Young Adults with Pervasive Developmental Disorders (2010)
  • Author(s): Kosaka H, et al.
  • Journal Title: Neuroimage. Volume: 50(4) Pages: 1357-1363
  • Peer Reviewed
• [Journal Article] "Stay tuned": Inter-individual neural synchronization during mutual gaze and joint attention (2010)
  • Author(s): Saito DN, et al.,
  • Journal Title: Frontiers in Integrative Neuroscience Volume: 4 Pages: 127-127
  • Peer Reviewed
• [Journal Article] Smaller Insula and Inferior Frontal Volumes in Young Adults with Pervasive Developmental Disorders. (2010)
  • Author(s): Kosaka H, et al.
  • Journal Title: NeuroImage Volume: 50(4) Pages: 1357-1363
  • Peer Reviewed
• [Journal Article] 青年期広汎性発達障害者の脳灰白質減少-VBM研究- (2009)
  • Author(s): 小坂浩隆、等
  • Journal Title: 臨床脳波 Volume: 51(8) Pages: 483-489
  • Peer Reviewed
• [Journal Article] 青年期広汎性発達障害者の脳灰白質減少 -VBM研究- (2009)
  • Author(s): 小坂浩隆, ら
  • Journal Title: 臨床脳波 51 Pages: 483-489
  • Peer Reviewed
• [Journal Article] Emotional responses associated with self-face processing in individuals with autism spectrum disorders : An fMRI study
  • Author(s): Morita T, Kosaka H, et al
  • Journal Title: Social Neuroscience Volume: (in press)
  • Peer Reviewed
• [Journal Article] Smaller Insula and Inferior Frontal Volumes in Young Adults with Pervasive Developmental Disorders.
  • Author(s): Kosaka H, et al.
  • Journal Title: NeuroImage (in press)
  • Peer Reviewed
• [Presentation] Functional MRI researches in patients with autism spectrum disorders (2013)
  • Author(s): Kosaka H
  • Organizer: Scientifoc Forum for Autism Spectrum Disorder
  • Place of Presentation: Ishikawa, Japan, シンポジウム
  • Year and Date: 2013-02-16
• [Presentation] Social behaviors of autistic disorder are improved by long-term oxytocin administration: a case of 16-year-old girl (2012)
  • Author(s): Kosaka H, et al
  • Organizer: The 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, USA, ポスター
  • Year and Date: 2012-10-14
• [Presentation] Neuroimaging and Oxytocin effect in Youth with Autism Spectrum Disorders (2012)
  • Author(s): Kosaka H.
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Japan, シンポジウム
  • Year and Date: 2012-10-01
• [Presentation] 「社会脳科学:領域を超えた融合と発展」自閉症スペクトラム障害の社会性障害を探る: fMRI研究 (2012)
  • Author(s): 小坂浩隆
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸、シンポジウム
  • Year and Date: 2012-09-29
• [Presentation] 自閉症スペクトラム障害の顔認知と対人同調の不全: fMRI研究 (2012)
  • Author(s): 小坂浩隆
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 愛知、シンポジウム
  • Year and Date: 2012-09-20
• [Presentation] Is it easy for autistic people to think about an autistic character's behavior in a story? The effect of similarity between readers and characters in recognition (2012)
  • Author(s): Komeda H, Kosaka H, et al
  • Organizer: The 22nd Annual Meeting of the Society for Text & Discourse
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2012-07-10
• [Presentation] Self-Related Representation in Individuals with High-Functioning Autism (2012)
  • Author(s): Komeda H, Kosaka H, et al
  • Organizer: The 10th International Meeting for Autism Research (IMFAR)
  • Place of Presentation: Toronto, Canada, ポスター
  • Year and Date: 2012-05-17
• [Presentation] 青年期自閉症スペクトラム障害の脳研究 (2012)
  • Author(s): 小坂浩隆
  • Organizer: 第7回統合失調症学会学術集会
  • Place of Presentation: 名古屋、愛知、シンポジウム
  • Year and Date: 2012-03-16
• [Presentation] Self-Related Representation in Individuals with High-Functioning Autism (2012)
  • Author(s): Komeda H et al.,
  • Organizer: The 10th International Meeting for Autism Research (IMFAR)
  • Place of Presentation: San Diego, California, USA
• [Presentation] 広汎性発達障害患者におけるrisperidoneからaripiprazoleへの置換に関する後方視的検討 (2012)
  • Author(s): 浅野 みずき 等
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌、北海道
• [Presentation] Is it easy for autistic people to think about an autistic character’s behavior in a story? The effect of similarity between readers and characters in recognition. (2012)
  • Author(s): Komeda H et al.,
  • Organizer: The 22nd Annual Meeting of the Society for Text & Discourse
  • Place of Presentation: Montreal, Canada
• [Presentation] Deficits in facial recognition and inter-individual neural synchronization in autism spectrum disorders: fMRI studies. 自閉症スペクトラム障害の顔認知と対人同調の不全: fMRI研究 (2012)
  • Author(s): Kosaka H.
  • Organizer: The 35th Annual Meeting of Japan Neuroscience Society 第35回日本神経科学大会
  • Place of Presentation: Nagoya, Aichi
  • Invited
• [Presentation] 「社会脳科学：領域を超えた融合と発展」 自閉症スペクトラム障害の社会性障害を探る: fMRI研究 (2012)
  • Author(s): 小坂 浩隆
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸、兵庫
  • Invited
• [Presentation] Neuroimaging and Oxytocin effect in Youth with Autism Spectrum Disorders (2012)
  • Author(s): Kosaka H.
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe, Hyogo
  • Invited
• [Presentation] Social behaviors of autistic disorder are improved by long-term oxytocin administration: a case of 16-year-old girl. (2012)
  • Author(s): Kosaka H.
  • Organizer: The 42th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: New Orleans, USA
• [Presentation] ASD/ADHD児を対象とした前頭葉機能評価に関する研究 (2012)
  • Author(s): 新井 清義 等
  • Organizer: 第53回日本児童青年精神医学会
  • Place of Presentation: 東京
• [Presentation] 描画検査が虐待の早期発見・介入につながった被虐待児の１例 (2012)
  • Author(s): 浅野 みずき 等
  • Organizer: 第32回日本精神科診断学会
  • Place of Presentation: 宜野湾、沖縄
• [Presentation] 青年期自閉症スペクトラム障害の脳研究 (2012)
  • Author(s): 小坂浩隆
  • Organizer: 第7回統合失調症学会学術集会
  • Place of Presentation: 愛知(招待講演)
• [Presentation] Oxytocin effect in young males with autism spectrum disorders: Aneye-tracking study (2011)
  • Author(s): Kosaka H, et al.
  • Organizer: Exploring Autism Research Collaboration Between Japan and United States Joint Academic Conference on Autism Spectrum Disorders
  • Place of Presentation: Tokyo, Japan, ポスター
  • Year and Date: 2011-12-02
• [Presentation] Oxytocin facilitates eye contact in young males with autism spectrum disorders (2011)
  • Author(s): Kosaka H, et al
  • Organizer: The 41th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA, ポスター
  • Year and Date: 2011-11-12
• [Presentation] 自閉症スペクトラムにおけるExtrastriate body area (EBA) の機能低下-相互模倣時の自他の動作の比較にかかわる神経基盤 (2011)
  • Author(s): 岡本悠子、小坂浩隆、等
  • Organizer: 第34回日本神経科学大会-こころの脳科学-
  • Place of Presentation: 神奈川
  • Year and Date: 2011-09-14
• [Presentation] 高機能自閉症スペクトラム成人の物語読解 (2011)
  • Author(s): 米田英嗣、小坂浩隆、等
  • Organizer: 第10回日本自閉症スペクトラム学会
  • Place of Presentation: 愛知
  • Year and Date: 2011-09-11
• [Presentation] 自閉症スペクトラムにおけるEBAの機能低下-相互模倣時の自他の動作の比較に関わる神経基盤 (2011)
  • Author(s): 岡本悠子、小坂浩隆、等
  • Organizer: 第13回日本ヒト脳機能マッピング学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-01
• [Presentation] Neural substrates of joint attention and inter-individual functional connectivity during mutual gaze in individuals with normal and autism spectrum disorders using dual functional MRI. (2011)
  • Author(s): Tanabe HC, Kosaka H, et al
  • Organizer: The 17th annual meeting of the Organization for Human Brain Mapping (OHBM)
  • Place of Presentation: Quebec, Canada, ポスター
  • Year and Date: 2011-06-26
• [Presentation] Neural substrates of joint attention and inter-individual functional connectivity during mutual gaze in individuals with normal and autism spectrum disorders using dual functional MRI (2011)
  • Author(s): Tanabe HC, Kosaka H, et al
  • Organizer: The 17th annual meeting of OHBM
  • Place of Presentation: Quebec, Canada
• [Presentation] Oxytocin facilitates eye contact in young males with autism spectrum disorders (2011)
  • Author(s): Kosaka H, et al
  • Organizer: The 41th Annual Meeting of SfN
  • Place of Presentation: Washington DC, USA
• [Presentation] Oxytocin effect in young males with autism spectrum disorders : Aneye-tracking study (2011)
  • Author(s): Kosaka H, et al
  • Organizer: Exploring Autism Research Collaboration Between Japan and United States Joint Academic Conference on Autism Spectrum Disorders
  • Place of Presentation: Tokyo, Japan
• [Presentation] 経鼻オキシトシン投与は自閉症スペクトラム障害者の目の領域への注視時間を延長する (2011)
  • Author(s): 小坂浩隆, 他
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] The EBA dysfunction in the autism spectrum disorders (ASD) ; as a "comparator" of self and other's action during reciprocal imitation (2011)
  • Author(s): 岡本悠子、小坂浩隆, 他
  • Organizer: 第34回日本神経科学大会-こころの脳科学-
  • Place of Presentation: 神奈川
• [Presentation] 広汎性発達障害における自己評価プロセス:fMRI研究 (2010)
  • Author(s): 守田知代、小坂浩隆、等
  • Organizer: Nuero 2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Correlations Between Smaller Brain Volume and Autism Spectrum Quotient or Intelligence Quotient in Young Male Adults with Pervasive Developmental Disorders (2010)
  • Author(s): Kosaka H, et al
  • Organizer: The 4th International Workshop on Biomedical Imaging (Fukui 2010)
  • Place of Presentation: Fukui, Japan、口演&ポスター
  • Year and Date: 2010-01-25
• [Presentation] Correlations Between Smaller Brain Volume and Autism Spectrum Quotient or Intelligence Quotient in Young Male Adults with Pervasive Developmental Disorders. (2010)
  • Author(s): Kosaka H, et al.
  • Organizer: The 4th International Workshop on Biomedical Imaging
  • Place of Presentation: Fukui, Japan
  • Year and Date: 2010-01-25
• [Presentation] Cingulate cortex dysfunction during self-face evaluation in pervasive developmental disorders.Japan-US Brain Research Workshop (2010)
  • Author(s): Morita T, Kosaka H, et al
  • Organizer: Development of social brain
  • Place of Presentation: Development of social brain
  • Year and Date: 2010-01-23
• [Presentation] Abnormal self-awareness in pervasive developmental disorders. (2009)
  • Author(s): Morita T, Kosaka H, et al.
  • Organizer: International Symposium: New Frontiers in Social Cognitive Neuroscience
  • Place of Presentation: Sendai, Miyagi, Japan
  • Year and Date: 2009-11-27
• [Presentation] Abnormal self-awareness in pervasive developmental disorders. (2009)
  • Author(s): Morita T, Kosaka H, et al.
  • Organizer: International Symposium : New Frontiers in Social Cognitive Neuroscience.
  • Place of Presentation: Miyagi, Japan
  • Year and Date: 2009-11-27
• [Presentation] Decreased bilateral insulae volume in youth with pervasive developmental disorders. (2009)
  • Author(s): Kosaka H, et al.
  • Organizer: Asian and Oceanian Congress on Clinical Neurophysiology 2009
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-04-17
• [Presentation] Differential amygdala response to lower face in patients with pervasive developmental disorder : an fMRI study. (2009)
  • Author(s): Ishitobi M, Kosaka H, et al.
  • Organizer: Asian and Oceanian Congress on Clinical Neurophysiology 2009
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-04-17
• [Presentation] Decreased bilateral insulae volume in youth with pervasive developmental disorders (2009)
  • Author(s): Kosaka H, et al
  • Organizer: 2009 Asian and Oceanian Congress on Clinical Neurophysiology (AOCCN)
  • Place of Presentation: Seoul, Korea, ポスター
  • Year and Date: 2009-04-16
• [Presentation] Differential amygdala response to lower face in patients with pervasive developmental disorder: an fMRI study. (2009)
  • Author(s): Ishitobi M, Kosaka H, et al
  • Organizer: 2009 Asian and Oceanian Congress on Clinical Neurophysiology (AOCCN)
  • Place of Presentation: Seoul, Korea, ポスター
  • Year and Date: 2009-04-16
• [Presentation] Functional MRI researches in patients with autism spectrum disorders.
  • Author(s): Kosaka H.
  • Organizer: Scientifoc Forum for Autism Spectrum Disorder.
  • Place of Presentation: Kanazawa, Ishikawa
  • Invited