Microglial activation and white matter abnormality in autism : MRI and PET study
| Project/Area Number |
21791124
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKEBAYASHI Kiyokazu Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 特任助教 (50397428)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自閉症 / 軸索 / ミクログリア / 脳画像 |
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| Research Abstract |
Patients with autism had significantly higher [11C](R)-PK11195 BPs than control subjects in the ROIs ; brain stem, cerebellum, thalamus, frontal, temporal, and occipital lobe, compared to healthy comparison subjects. This results suggests that there are microglial activation in those brain areas in autism, which indicates that neuroinflammation underlies the pathology of autism.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders.2011
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N.
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Journal Title
Arch Gen Psychiatry. 68(3)
Pages: 306-313
Related Report
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[Journal Article] Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders.2011
Author(s)
Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K, Tsuchiya KJ, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Mori N
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Journal Title
PLoS One. 6(5)(Epub 2011 May 27)
Related Report
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