VLDLR overexpression rat : evaluation as an animal model of autism

• Project/Area Number: 21791126
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: IWATA Keiko Hamamatsu University School of Medicine, 子どものこころの発達研究センター, 助教 (30415088)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 児童 / 思春期精神医学 / 自閉症 / ラット / VLDLR / Reelin

Research Abstract

It has been reported that level of VLDLR mRNA was increased in post mortem studies of autistic brain. In this study, we generated transgenic (Tg) rats overexpressing VLDLR and examined its histological and behavioral features. Results indicated that the spontaneous locomotor activity in Tg rats was significantly increased without detectable changes in histology. Additionally, Tg rats tended to show performance deficits in radial maze, suggesting that spatial working memory was slightly impaired. These results suggest that VLDLR level might be involved in locomotor activity and memory function. Patients with neurodevelopmental or psychiatric disorders do not show striking neuroanatomical aberration. Therefore, it is significant for the clinical aspect that these behavioral phenotypes were detected without neuroanatomical abnormality in VLDLR Tg rats.

Research Products

• [Journal Article] Animal models of autism : an epigenetic and environmental viewpoint. (2010)
  • Author(s): Iwata K, Matsuzaki H, Takei N, Manabe T, Mori N.
  • Journal Title: Journal of Central Nervous System Disease 2 Pages: 37-44
• [Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder. (2010)
  • Author(s): Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34 Pages: 1007-1010
• [Journal Article] Novel Events in Mitchondria : Increase of Poly(ADP-ribosyl)ation in Human Promyelocytic Leukemia HL-60 Cell Line during Differentiation by Nicotinamide. (2010)
  • Author(s): Iwata, K., Ogata, S., Taguchi, H.
  • Journal Title: Process Biochemistry 45 Pages: 54-59
• [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis. (2010)
  • Author(s): Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. B 153 Pages: 1221-1227
• [Journal Article] Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats : reversal by fluoxetine. (2010)
  • Author(s): Suzuki K, Okada K, Wakuda T, Shinmura C, Kameno Y, Iwata K, Takahashi T, Suda S, Matsuzaki H, Iwata Y, Hashimoto K, Mori N.
  • Journal Title: PLoS One 17;5(2)
  • NAID: 120005314217
• [Journal Article] Decreased serum levels of adiponectin in subjects with autism. (2010)
  • Author(s): Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34 Pages: 455-458
• [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism. (2010)
  • Author(s): Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry 34 Pages: 154-158
• [Journal Article] Animal models of autism : an epigenetic and environmental viewpoint. (2010)
  • Author(s): Iwata K, Matsuzaki H, Takei N, Manabe T, Mori N.
  • Journal Title: Journal of Central Nervous System Disease Volume: 2 Pages: 37-44
  • Peer Reviewed
• [Journal Article] Failure to confirm genetic association of the FXYD6 gene with schizophrenia : the Japanese population and meta-analysis. (2010)
  • Author(s): Iwata Y, Yamada K, Iwayama Y, Anitha A, Thanseem I, Toyota T, Hattori E, Ohnishi T, Maekawa M, Nakamura K, Suzuki K, Matsuzaki H, Tsuchiya KJ, Suda S, Sugihara G, Takebayashi K, Yamamoto S, Iwata K, Mori N, Yoshikawa T.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. Volume: 153B Pages: 1221-7
  • Peer Reviewed
• [Journal Article] Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressivedisorder. (2010)
  • Author(s): Suzuki K, Iwata Y, Matsuzaki H, Anitha A, Suda S, Iwata K, Shinmura C, Kameno Y, Tsuchiya KJ, Nakamura K, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 34 Pages: 1007-10
  • Peer Reviewed
• [Journal Article] Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats : reversal by fluoxetine. (2010)
  • Author(s): Suzuki K, Okada K, Wakuda T, Shinmura C, Kameno Y, Iwata K, Takahashi T, Suda S, Matsuzaki H, Iwata Y, Hashimoto K, Mori N.
  • Journal Title: PLoS One 17
  • NAID: 120005314217
  • Peer Reviewed
• [Journal Article] Decreased serum levels of adiponectin in subjects with autism (2010)
  • Author(s): Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M, Shinmura C, Iwata Y, Suda S, Tsuchiya KJ, Matsumoto K, Sugihara G, Iwata K, Yamamoto S, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34 Pages: 455-458
  • Peer Reviewed
• [Journal Article] Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism. (2010)
  • Author(s): Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K, Suda S, Tsuchiya KJ, Matsumoto K, Iwata Y, Nakamura K, Tsujii M, Sugiyama T, Takei N, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. 34 Pages: 154-158
  • Peer Reviewed
• [Presentation] VLDLR overexpression rat : evaluation as an animal model of autism. (2010)
  • Author(s): Iwata, K., Matsuzaki, H., Izumo, N., Ichitani, Y., Mori, N.
  • Organizer: Society for neuroscience 2010
  • Place of Presentation: San Diego, California
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 高機能自閉症の発症危険度を判定する方法およびマーカー (2010)
  • Inventor(s): 森則夫、中村和彦、鈴木勝昭、土屋賢治、岩田圭子、松崎秀夫
  • Industrial Property Rights Holder: 国立大学法人 浜松医科大学
  • Filing Date: 2010-10-14