| Project/Area Number |
21791137
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Oita University |
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Principal Investigator |
TSURU Jusen Oita University, 医学部, 助教 (50527752)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 不安障害 / うつ病 / アミラーゼ / DEX / CRH / コルチゾー |
|---|
| Research Abstract |
Chronic stress has often induced dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis by. In comparison, psychosocial stress-induced activation of salivary α-amylase (sAA) functions as a marker of sympathoadrenal medullary system (SAM) activity. The present study measured sAA and salivary cortisol levels in patients with major depressive disorder. Tension-Anxiety, Depression-Dejection, Anger-Hostility, Fatigue, and Confusion scores in patients with major depressive disorder were significantly increased compared to healthy controls. SAA levels in major depressive disorder patients were significantly elevated compared with controls both before and after electrical stimulation. These preliminary results suggest that sAA might be a useful biological marker of major depressive disorder.
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