Clinicopathological study
| Project/Area Number |
21791142
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Juntendo University (2010-2011)
Yokohama City University (2009) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISEKI Eizo 順天堂大学, 医学部, 教授 (30203061)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | レビー小体病 / レビー小体型認知症 / アルツハイマー病 / 老人斑 / アミロイド / パーキンソン病 / レビー小体 / 神経原線維変化 / タウ / 認知症 / DLB / 画像 / 神経病理 |
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| Research Abstract |
Dementia with Lewy bodies is the second most common neurodegenerative dementing disorder after Alzheimer's disease. Cerebral amyloid deposition may contribute to the timing of the onset of dementia relative to that of parkinsonism in Lewy body dementia, suggesting that further clinicopathological investigation will be needed.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Neuropathological investigation of the hypometabolic regions on positron emission tomography with [18F] fluorodeoxyglucose in patients dementia with Lewy bodies2012
Author(s)
Kasanuki K, Iseki E, Fujishiro H, Yamamoto R, Higashi S, Minegishi M, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H
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Journal Title
J Neurological sciences
Volume: 314
Pages: 111-119
Related Report
Peer Reviewed
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[Journal Article] Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies2011
Author(s)
Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo T, Katsuse O, Uchikado H, Furukawa Y, Hino H, Kosaka K, Sato K, Arai H, Wada K, Iseki E
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Journal Title
J Neuropathol Exp Neurol
Volume: 70
Pages: 264-280
Related Report
Peer Reviewed
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[Journal Article] Gray matter lesions in Nasu-Hakola disease : A report on three autopsy ca2011
Author(s)
Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Anno M, Kosaka K, Akiyama H, Hirayasu Y
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Journal Title
Neuropathology
Volume: 31
Issue: 2
Pages: 135-143
DOI
Related Report
Peer Reviewed
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[Journal Article] Incidental Lewy body disease : do some cases represent preclinical dementia with Lewy bodies?2011
Author(s)
Frigerio R, Fujishiro H, Ahn TB, Josephs KA, Maraganore D, DelleDonne A, Parisi JE, Klos K, Boeve B, Dickson DW, Ahlskog JE
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Journal Title
Neurobiol Aging
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Gray matter lesions in Nasu-Hakola disease : a report on three autopsy cases.2011
Author(s)
Aoki N, Tsuchiya K, Togo T, Kobayashi Z, Uchikado H, Katsuse O, Suzuki K, Fujishiro H, Arai T, Iseki E, Kosaka K, Akiyama H, Hirayasu Y.
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Journal Title
Neuropathology
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Distribution of cerebral amyloid deposition and its relevance to clinical phenotype in Lewy body dementia2010
Author(s)
Fujishiro H, Iseki E, Higashi S, Kasanuki K, Murayama N, Togo T, Katsuse O, Uchikado H, Aoki N, Kosaka K, Arai H, Sato K
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Journal Title
Neurosci Letters
Volume: 486
Pages: 19-23
Related Report
Peer Reviewed
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[Journal Article] Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.2010
Author(s)
Arai T, Hasegawa M, Nonoka T, Kametani F, Yamashita M, Hosokawa M, Niizato K, Tsuchiya K, Kobayashi Z, Ikeda K, Yoshida M, Onaya M, Fujishiro H, Akiyama H.
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Journal Title
Neurapathology
Volume: 30
Pages: 170-181
NAID
Related Report
Peer Reviewed
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[Journal Article] Comparison of risk factor profiles in incidental Lewy body disease and Parkinson disease.2009
Author(s)
Frigerio R, Fujishiro H, Maraganore DM, Klos KJ, DelleDonne A, Heckman MG, Crook JE, Josephs KA, Parisi JE, Boeve BF, Dickson DW, Ahlskog JE.
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Journal Title
Arch Neruol 66
Pages: 1114-1119
Related Report
Peer Reviewed
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[Presentation] Distribution ofβ-amyloid deposition and its clinical relevance in dementia with Lewy bodies : a pathological study2010
Author(s)
Fujishiro H, Iseki E, Higashi S, Kasanuki K, Yamamoto R, Togo T, Katsuse O, Uchikado H, Kosaka K, Arai H, Sato K
Place of Presentation
Honolulu, U. S. A.
Year and Date
2010-07-12
Related Report
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[Presentation] Variability of cognitive conditions in individuals showing diffuse occipital hypometabolism on^<18> F-FDG PET scans2010
Author(s)
Fujishiro H, Iseki E, Murayama N, Kasanuki K, Ota K, Higashi S, Yamamoto R, Suzuki M, Arai H, Sato K
Organizer
Alzheimer's Association International Conference on Alzheimer's Disease
Place of Presentation
Honolulu, U. S. A.
Year and Date
2010-07-10
Related Report
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[Presentation] Phosphorylated TDP-43 in neurodegenerative disorders.2009
Author(s)
Arai T, Mackenzie IRA, Hasegawa M, Fujishiro H, Nonoka T, Niizato K, Tsuchiya K, Kobayashi Z, Iritani S, Onaya M, Akiyama H.
Organizer
Alzheimer's Association International Conference on Alzheimer's Disease.
Place of Presentation
ウイーン
Year and Date
2009-07-13
Related Report
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[Presentation] 那須-Hakola病における灰白質病変の検討2009
Author(s)
青木直哉, 土谷邦秋, 都甲崇, 内門大丈, 勝瀬大海, 鈴木京子, 安野みどり, 藤城弘樹, 新井哲明, 井関栄三, 小阪憲司, 秋山治彦, 平安良雄
Organizer
第50回 日本神経病理学会総会学術研究会
Place of Presentation
高松
Year and Date
2009-06-06
Related Report
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