An Analysis of Pharmacotherapy Combined Cognitive-Behavioral Group Therapy for Panic Disorder with Agoraphobia
| Project/Area Number |
21791147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | パニック障害 / 広場恐怖 / 薬物療法 / 認知行動療法 / 治療因子 |
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| Research Abstract |
It is well known that combination of cognitive-behavioral therapy and pharmacotherapy(the combination therapy) for panic disorder(PD) with agoraphobia is effective. However, there has been little research on the most favorable drug for the combination therapy. The purpose of this study was to examine which drug for the combination therapy is best to improve symptoms of panic disorder with agoraphobia.
Out patients were recruited between October 2008 and March 2011 and assigned to pharmacotherapy at Showa university hospital. Pharmacotherapists were free to choose the drug for patients. We used Panic disorder severity scale(PDSS), Hamilton Rating Scale for Anxiety(HRSA), Global Assessment of Functioning Scale(GAF), Hospital Anxiety Depression Scale(HADS), Agoraphobic Cognitions Questionnaire(ACQ), Body Sensations Questionnaire(BSQ), Clinical Global Impression(CGI)-Severity & Improvement for assessment. Outcomes were assessed before(pretest) and after(protest : 12weeks) pharmacotherapy co
… More
mbined 10 times cognitive-behavioral group therapy(CBGT).
Forty-one patients improved significantly from pretest to posttest on PDSS for Japanese, which was primary outcome measure. At posttrearment, all scales improved significantly by Temporary use of benzodiazepines more than Regular use. We supposed that temporary using benzodiazepine is least disruptive to the combination therapy, while regular using benzodiazepine interferes with CBT, which works on frontal cortex. In contrast, using antidepressant, antipsychotic and moodstabilizer had little influence on outcomes in this study. PD with SSRI are changed the typical cognition of panic disorder faster than without SSRI, while both regular and temporary using benzodiazepine improved at the same time.
In summary, the results from our clinical trial provide support that the combination therapy is efficacious for panic disorder with agoraphobia. SSRI and a single dose of benzodiazepine are recommended for the combination therapy. SSRI can change the typical cognition of panic disorder faster. Temporary using benzodiazepine is more effective than regular using benzodiazepine at posttreatment of CBGT. Less
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] パニック障害における集団認知行動療法の治療効果の検討-集団認知行動療法との併用時に最も相応しい薬物療法に関する研究-2012
Author(s)
高塩理, 小久保羊介, 秋田亮, 田中宏明, 阪上和美, 清水英之, 岡島由佳, 中村暖, 明石憲尚, 加藤進昌
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Journal Title
日本神経精神薬理学雑誌
Volume: Vol.32, No.2
Pages: 109-111
NAID
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[Presentation] An Analysis of Pharmacotherapy Combined Cognitive-Behavioral Group Therapy for Panic Disorder with Agoraphobia2011
Author(s)
Osamu Takashio, MD, Yousuke Kokubo, MD, Ryou Akita, R.A., Hiroaki Tanaka, R.A., Kazumi Sakagami, R.A., Hideyuki Shimizu, R.A., Yuka Okajima, MD, Dan Nakamura, R.A., Norihisa Akashi, R.A., Nobumasa Kato, MD
Organizer
2nd Congress of Asian College of Neuropsychopharmacology
Place of Presentation
Korea, Seoul
Related Report
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