PET study of dopamine receptor and psychiatric symptoms in patients with temporal epilepsy

Research Project

Project/Area Number	21791150
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Psychiatric science
Research Institution	Nippon Medical School
Principal Investigator	ICHIMIYA Tetsuya Nippon Medical School, 医学部, 講師 (50398864)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	PET / ドパミンD2 / 側頭葉てんかん / ドパミンD2受容体 / FLB 457 / SPM
Research Abstract	Nine patients with left temporal lobe epilepsy and age-matched 14 healthy control subjects participated in this study. Binding potential of dopamine D2 receptors were examined using positron emission tomography. Parametric images of binding potentials were created and compared between groups. Binding potentials in the left temporal lobe, left inferior temporal lobe, left fusiform gyrus were decreased in patients compared to control subject. This could indicate decreased dopamine D2 neurotransmission in the ipsilateral temporal lobe.