Optimization of electroconvulsive therapy for drug-resistant depression based on neurotrophic factor dynamics as a prognostic factor

• Project/Area Number: 21791151
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Nippon Medical School
• Principal Investigator: IKEDA Yumiko 日本医科大学, 医学部, 助教 (10386154)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: うつ病 / ECT / 神経栄養因子 / 電気痙攣療法

Research Abstract

Level of serum brain-derived neurotrophic factor(BDNF) and Hamilton rating scale for depression symptoms were measured before, during and after electroconvulsive therapy(ECT) in patients with depression. Increased BDNF level was shown immediately after ECT, followed by improvement of the depressive symptoms. Increased BDNF level was maintained for 4 weeks after completion of ECT, while the depressive symptoms recurred 1 week after completion of ECT. These results show relationship between temporal dynamics of serum neurotrophic factor and severity of depressive symptoms induced by ECT.

Research Products

• [Journal Article] Functional magnetic resonance imaging study on the effects of acute single administration of paroxetine on motivation-related brain activity (2011)
  • Author(s): Marutani, T., Yahata, N., Ikeda, Y., Ito, T., Yamamoto, M., Matsuura, M., Okubo, Y., Matsushima, E., Suzuki, H. & Matsuda, T.
  • Journal Title: Psychiatry Clin Neurosci Volume: 65 Issue: 2 Pages: 191-198
  • DOI: 10.1111/j.1440-1819.2011.02189.x
  • Peer Reviewed
• [Journal Article] Behavioral destabilization induced by the selective serotonin reuptake inhibitor fluoxetine (2011)
  • Author(s): Kobayashi K, Ikeda Y, Suzuki H.
  • Journal Title: Mol Brain Volume: 4 Issue: 1 Pages: 12-12
  • DOI: 10.1186/1756-6606-4-12
  • Peer Reviewed
• [Journal Article] A local anesthetic, ropivacaine, suppresses activated microglia via a nerve growth factor-dependent mechanism and astrocytes via a nerve growth factor-independent mechanism in neuropathic pain (2011)
  • Author(s): Toda S, Sakai A, Ikeda Y, Sakamoto A, Suzuki H.
  • Journal Title: Mol Pain Volume: 7 Pages: 2-2
  • DOI: 10.1186/1744-8069-7-2
  • Peer Reviewed
• [Journal Article] Reversal of hippocampal neuronal maturation by serotonergic antidepressants (2010)
  • Author(s): Kobayashi K, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T, Suzuki H.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107 Issue: 18 Pages: 8434-9
  • DOI: 10.1073/pnas.0912690107
  • Peer Reviewed
• [Journal Article] Auditory load-dependent cerebral activation during the diotic listening task: an fMRI study (2010)
  • Author(s): Ikeda, Y., Yahata, N., Takahashi, H., Koeda, M., Asai, H., Okubo, Y. & Suzuki, H.
  • Journal Title: Neurosci. Res Volume: 67 Issue: 1 Pages: 65-71
  • DOI: 10.1016/j.neures.2010.02.006
  • Peer Reviewed
• [Presentation] 注意ネットワークに及ぼすカフェインの効果:薬理学的fMRI研究 (2012)
  • Author(s): 池田裕美子
  • Organizer: 日本薬理学会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-16
• [Presentation] 健常者における注意ネットワークに対するカフェインの効果:薬理学的fMRI研究 (2011)
  • Author(s): 池田裕美子
  • Organizer: 日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15