| Project/Area Number |
21791153
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
SHIBASAKI Masahiro Kawasaki Medical School, 医学部, 助教 (80412162)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 覚せい剤 / 麻薬 / 精神依存 / L型カルシウムチャネル / 細胞内Ca2+動態 / 神経可塑性 / シナプス形成 / actin depolymerizing factor / 薬物依存 / Methamphetamine / Morphine / High voltage-gated calcium channel / Vps34 / 細胞内Ca^2+応答 / Nifedipine |
|---|
| Research Abstract |
Administration of nifedipine dose-dependently reduced the development of methamphetamine- and morphine-induced rewarding effect. Under the conditions, protein levels of L-type VDCC in the limbic forebrain were significantly increased on methamphetamine- and morphine-induced rewarding effects. The up-regulation was regulated by Vps34 relating intracellular vesicular traffic. Furthermore, enhancement of Ca2+ response by L-type VDCC induced increase of ADF and development of dependence on methamphetamine and morphine.
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