Development of treatment for drug addiction : Reversal of sensitization by dopamine D1 receptor signaling

• Project/Area Number: 21791154
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Kurume University
• Principal Investigator: SHUTO Takahide Kurume University, 医学部, 助教 (70412541)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 精神薬理学 / 薬物依存 / ドーパミン / メタンフェタミン / 逆耐性 / DARPP-32 / 線条体

Research Abstract

Repeated administration of the dopamine D1 receptor agonist induces the reversal of established behavioral sensitization to methamphetamine, which is thought as a model of drug addiction. These findings raise a plausible mechanism that chronic dopamine D1 receptor agonism counteracts the decreased dopamine D1 receptor signaling in the sensitized state, leading to the reversal of sensitization.

Research Products

• [Journal Article] Treatment of the psychostimulant-sensitized animal model of schizophrenia. (2011)
  • Author(s): Shuto T, Nishi A.
  • Journal Title: CNS Neurosci Ther. 17 Pages: 133-139
  • Peer Reviewed
• [Journal Article] Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia. (2011)
  • Author(s): Takahide Shuto
  • Journal Title: CNS Neurosci Ther. Volume: 17 Pages: 133-139
  • Peer Reviewed
• [Presentation] ムスカリン受容体による線条体ドーパミン情報伝達系の調節 (2011)
  • Author(s): 黒岩真帆美
  • Organizer: 第84回 日本薬理学会年会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-03-23
• [Presentation] sirtuin を活性化するresveratrol のコカイン逆耐性現象に対する影響 (2011)
  • Author(s): 古賀夕貴, 首藤隆秀, 黒岩真帆美, 豊増功次, 西昭徳
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 誌上開催
  • Year and Date: 2011-03-22
• [Presentation] sirtuinを活性化するresveratrolのコカイン逆耐性現象に対する影響 (2011)
  • Author(s): 古賀夕貴
  • Organizer: 第84回 日本薬理学会年会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-03-22
• [Presentation] Regulation of DARPP-32 phosphorylation by muscarinic receptors via presynaptic and postsynaptic mechanisms in the stiriatum. (2010)
  • Author(s): 黒岩真帆美
  • Organizer: 第63回 日本薬理学会西南部会
  • Place of Presentation: かごしま県民交流センター(鹿児島県)
  • Year and Date: 2010-11-26
• [Presentation] 大脳皮質ドーパミンD1シグナルを制御するホスホジエステラーゼ4に関する研究 (2010)
  • Author(s): 黒岩真帆美
  • Organizer: 第40回 日本神経精神薬理学会年会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2010-09-17
• [Remarks] ホームページ等
  • URL: http://www.med.kurume-u.ac.jp/med/pharm/