Development of treatment for drug addiction : Reversal of sensitization by dopamine D1 receptor signaling
| Project/Area Number |
21791154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Kurume University |
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Principal Investigator |
SHUTO Takahide Kurume University, 医学部, 助教 (70412541)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 精神薬理学 / 薬物依存 / ドーパミン / メタンフェタミン / 逆耐性 / DARPP-32 / 線条体 |
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| Research Abstract |
Repeated administration of the dopamine D1 receptor agonist induces the reversal of established behavioral sensitization to methamphetamine, which is thought as a model of drug addiction. These findings raise a plausible mechanism that chronic dopamine D1 receptor agonism counteracts the decreased dopamine D1 receptor signaling in the sensitized state, leading to the reversal of sensitization.
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Report
(3 results)
Research Products
(8 results)
