| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Research Abstract |
We applied the voxel-based statistic approach by SPM8 for FA/ADC image and gray/white matter images obtained on MRI to estimate the brain microstructural change in narcolepsy and idiopathic hypersomnia, both which chief compliant is excessive daytime sleepiness. As a results, narcolepsy, regardless with or without cataplexy, showed reduced white matter volume of midbrain where the neural nuclei associated with maintenance of arousal exist, higher ADC in bilateral amygdala and left medial frontal area. Sleep efficiency showed negative correlation with ADC and FA in mainly right limbic area. These results indicate that the degree of axonal change is related with the disturbance in sleep maintenance system. Additionally, the pathogenesis of cataplexy might associated with abnormality in right precentral gyrus, right inferior frontal gyrus, right precuneus and left cerebellar tonsil. On the other hand, idiopathic hypersomnia showed FA abnormality in white matter distally along cerebral cortex of occipital, frontal and temporal area. As a conclusion, the mechanism of excessive daytime sleepiness is thought to be distinct between narcolepsy and idhiopathic hypersomnia.
|
