Development of a VEGFR3 imaging agent by PET for predictive diagnosis of lymph node metastasis.

Research Project

Project/Area Number	21791168
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	FURUMOTO Shozo Tohoku University, 大学院・医学系研究科, 准教授 (00375198)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	放射性医薬品 / 造影剤 / PET / VEGFR-3 / リンパ管新生 / リンパ節転移 / イメージング
Research Abstract	The purpose of this study was to develop a new radiolabeled imaging probe to visualize a VEGFR3 receptor, which is a key molecule in the early process of lymph node metastasis. Thus, imaging of VEGFR3 would be applicable to early diagnosis of lymph node metastasis. In this study, 11C-labeled VEGFR3 and its precursor for radiolabeling by methylation was successfully synthesized. Small animal PET imaging with the tracer showed a radioactivity uptake in tumor tissue in an AH109A tumor bearing rat.

Report

(3 results)