Clinical trial of proton beam therapy for the patients with hepatocellular carcinoma
| Project/Area Number |
21791170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MASASHI Mizumoto University of Tsukuba, 大学院・人間総合科学研究科, 講師 (20512388)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 粒子線治療 / 陽子線治療 / 肝細胞癌 / 最適化 |
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| Research Abstract |
The first year, we analyzed Dose Volume Histgram (DVH) of the patients with hepatocellular carcinoma (HCC) treated by proton beam therapy at University of Tsukuba. Along with this analysis, we reviewed late toxicity such as digestive tract ulcer, rib fracture and loss of liver function.
In the second year, we analyzed effectiveness and adverse event of proton beam therapy. In the result, we concluded that select optimal treatment schedule according to tumor location is useful to perform proton beam therapy safety. Especially the patients having HCC near the digestive tract need careful treatment to avoid digestive tract ulcer and bleeding.
And in this analysis, refractory HCC (such as large HCC, portal vein tumor thrombus and inferior vena tumor thrombus) could be well controlled by proton beam therapy without sever toxicity.
We also analyze the change of liver function after proton beam therapy. From this analysis, minimize the irradiated area of normal liver is important factor to keep good liver function after proton beam therapy.
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] Proton Beam Therapy for Hepatocellular Carcinoma : A Comparison of Three Treatment Protocols.2011
Author(s)
Mizumoto M, Okumura T, Hashimoto T, Fukuda K, Oshiro Y, Fukumitsu N, Abei M, Kawaguchi A, Hayashi Y, Ookawa A, Hashii H, Kanemoto A, Moritake T, Tohno E, Tsuboi K, Sakae T, Sakurai H
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Journal Title
International journal of radiation oncology biology physics Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] Radiotherapy for patients with metastases to the spinal column : a review of 603 patients at Shizuoka Cancer Center Hospital.2011
Author(s)
Mizumoto M, Harada H, Asakura H, Hashimoto T, Furutani K, Hashii H, Murata H, Takagi T, Katagiri H, Takahashi M, Nishimura T
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Journal Title
International journal of radiation oncology biology physics Vol.79
Pages: 208-213
Related Report
Peer Reviewed
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[Journal Article] Proton beam therapy for large hepatocellular carcinoma.2010
Author(s)
Sugahara S, Oshiro Y, Nakayama H, Fukuda K, Mizumoto M, Abei M, Shoda J, Matsuzaki Y, Thono E, Tokita M, Tsuboi K, Tokuuye K
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Journal Title
International journal of radiation oncology biology physics Vol.76
Pages: 460-466
NAID
Related Report
Peer Reviewed
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[Journal Article] Analysis of dose-volume histogram parameters for radiation pneumonitis after definitive concurrent chemoradiotherapy for esophageal cancer.2010
Author(s)
Asakura H, Hashimoto T, Zenda S, Harada H, Hirakawa K, Mizumoto M, Furutani K, Hironaka S, Fuji H, Murayama S, Boku N, Nishimura T
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Journal Title
Radiother Oncol Vol.95
Pages: 240-244
Related Report
Peer Reviewed
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[Journal Article] Phase I/II trial of hyperfractionated concomitant boost proton radiotherapy for supratentorial glioblastoma multiforme.2009
Author(s)
Mizumoto M, Tsuboi K, Igaki H, Yamamoto T, Takano S, Oshiro Y, Hayashi Y, Hashii H, Kanemoto A, Nakayama H, Sugahara S, Sakurai H, Matsumura A, Tokuuye K
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Journal Title
International journal of radiation oncology biology physics Vol.77
Pages: 98-105
Related Report
Peer Reviewed
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[Journal Article] Proton-beam therapy for hepatocellular carcinoma associated with portal vein tumor thrombosis.2009
Author(s)
Sugahara S, Nakayama H, Fukuda K, Mizumoto M, Tokita M, Abei M, Shoda J, Matsuzaki Y, Thono E, Tsuboi K, Tokuuye K
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Journal Title
Strahlenther Onkol Vol.185
Pages: 782-788
Related Report
Peer Reviewed
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