Research of aiming at the establishment of comprehensive diagnosis and therapy of metastatic bone cancer using novel radiopharmaceuticals

• Project/Area Number: 21791174
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kanazawa University
• Principal Investigator: OGAWA Kazuma Kanazawa University, 薬学系, 准教授 (30347471)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: イメージング / PET / 転移性骨腫瘍

Research Abstract

DOTA-conjugated bisphosphonate was synthesized using bisphosphonate as a carrier to bone. ^<67>Ga-DOTA-conjugated bisphosphonate was prepared with a radiochemical purity of over 95% without purification. In biodistribution experiments, ^<67>Ga-DOTA-conjugated bisphosphonate accumulated in bone rapidly but were hardly observed in tissues other than bone. These results indicate that ^<67>Ga-DOTA-conjugated bisphosphonate has ideal biodistribution characteristics as bone-imaging agents.

Research Products

• [Journal Article] Preparation and evaluation of a radiogallium complex-conjugated bis phosphonate as a bone scintigraphy agent (2011)
  • Author(s): K.Ogawa, K.Takai, H.Kanbara, T.Kiwada, Y.Kitamura, K.Shiba, A.Odani
  • Journal Title: Nuclear Medicine and Biology Volume: 38(in press)
  • Peer Reviewed
• [Journal Article] Preparation and evaluation of a radiogallium complex-conjugated bisphosphonate as a bone scintigraphy agent.
  • Author(s): K.Ogawa, K.Takai, H.Kanbara, T.Kiwada, Y.Kitamura, K.Shiba, A.Odani
  • Journal Title: Nucl Med Biol in press
  • NAID: 120002907443
  • Peer Reviewed
• [Presentation] 放射性ガリウム標識骨イメージング薬剤の開発研究 (2010)
  • Author(s): 高井健一郎、小川数馬、黄檗達人、北村陽二、柴和弘、小谷明
  • Organizer: 第10回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都テルサ(京都)
  • Year and Date: 2010-12-04
• [Presentation] 放射性ガリウム標識骨イメージング薬剤の開発研究 (2010)
  • Author(s): 高井健一郎、小川数馬、黄檗達人、北村陽二、柴和弘、小谷明
  • Organizer: 第10回放射性医薬品・画像診断薬研究会
  • Place of Presentation: 京都テルサ(京都府)
  • Year and Date: 2010-12-04
• [Presentation] 転移性骨腫瘍の診断を目的としたPET用薬剤の開発 (2010)
  • Author(s): 高井健一郎、小川数馬、黄檗達人、北村陽二、柴和弘、小谷明
  • Organizer: 日本薬学会北陸支部第122回例会
  • Place of Presentation: 北陸大学(石川県)
  • Year and Date: 2010-11-27
• [Presentation] Development and evaluation of a novel radiogallium labeled peptide as a bone imaging agent for PET (2010)
  • Author(s): K.Ogawa, K.Takai, H.Kanbara, T.Kiwada, Y.Kitamura, K.Shiba, A.Odani
  • Organizer: 240^th ACS National Meeting
  • Place of Presentation: Boston Convention Center (USA)
  • Year and Date: 2010-08-22
• [Presentation] Development and evaluation of a novel radiogallium labeled peptide as a bone imaging agent for PET (2010)
  • Author(s): K.Ogawa, K.Takai, H.Kanbara, T.Kiwada, Y.Kitamura, K.Shiba, A.Odani
  • Organizer: 240^<th> ACS National Meeting
  • Place of Presentation: Boston Convention Center (U.S.A.)
  • Year and Date: 2010-08-22
• [Presentation] Development of radiogallium-DOTA complex conjugated bone seeking compounds for PET bone imaging (2010)
  • Author(s): 高井健一郎, 小川数馬, 黄檗達人, 北村陽二, 柴和弘, 小谷明
  • Organizer: 第20回金属の関与する生体関連反応シンポジウム
  • Place of Presentation: 徳島文理大学国際会議場(徳島)
  • Year and Date: 2010-06-25
• [Presentation] Development of radiogallium-DOTA complex conjugated bone seeking compounds for PET bone imaging (2010)
  • Author(s): 高井健一郎, 小川数馬, 黄檗達人, 北村陽二, 柴和弘, 小谷明
  • Organizer: 第20回金属の関与する生体関連反応シンポジウム
  • Place of Presentation: 徳島文理大学国際会議場(徳島県)
  • Year and Date: 2010-06-25