Study on internal-radiotherapy with ^<64>Cu-ATSM targeting cancer stem cell-rich regions in tumors.

• Project/Area Number: 21791176
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: YOSHII Yukie University of Fukui, 高エネルギー医学研究センター, 特命助教 (10397242)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 画像診断学(含放射線診断学、核医学) / 内用放射線治療 / Positron Emission / Tomography / 腫瘍内低酸素 / がん幹細胞 / ^<64>Cu-ATSM / Positron Emission Tomography

Research Abstract

^<64>Cu-ATSM therapy resulted in inhibition of tumor growth, reduction of cancer stem cells, decrease of metastatic potential of tumors, suggesting the possibility of new internal-radiotherapy.

Research Products

• [Journal Article] ^<64>Cu-ATSMによる腫瘍内がん幹細胞ニッチイメージングと内用放射線治療への応用 (2011)
  • Author(s): 吉井幸恵、古川高子、清野泰、森哲也、吉井裕、岡沢秀彦、Michael J.Welch、藤林靖久
  • Journal Title: JSMI Reportトッピクス Volume: (In press)
• [Journal Article] Internal radiotherapy with copper-64-diacetyl-bis (N_4-methylthiosemicarbazone) reduces CD133^+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma (2011)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Tetsuya Mori, Hiroshi Yoshii, Tatsuya Asai, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi
  • Journal Title: Nuclear Medicine and Biology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Copper-64-diacetyl-bis (N^4-methylthiosemicarbazone) accumulates in rich regions of CD133^+ highly tumorigenic cells in mouse colon carcinoma (2011)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Atsuo Waki, Tetsuya Mori, Hiroshi Yoshii, Myungmi Oh, Tatsuya Asai, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi
  • Journal Title: Nuclear Medicine and Biology Volume: 35 Pages: 395-404
  • Peer Reviewed
• [Journal Article] Development of positron emission tomography imaging by ^<64>Cu-labeled Fab for detecting ERC/mesothelin in a mesothelioma mouse model. (2011)
  • Author(s): Chisato Yoshida, Chizuru Sogawa, Atsushi Tsuji, Hitomi Sudo, Aya Sugyo, Tomoya Uehara, Okio Hino, Yukie Yoshii, Yasuhisa Fujibayashi, Toshimitsu Fukumura, Mitsuru Koizumi, Yasushi Arano, Tsuneo Saga
  • Journal Title: Nuclear Medicine Communications Volume: 31 Pages: 380-388
  • Peer Reviewed
• [Journal Article] Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma. (2010)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Tetsuya Mori, Hiroshi Yoshii, Tatsuya Asai, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi.
  • Journal Title: Nuclear Medicine and Biology. in press
  • Peer Reviewed
• [Journal Article] Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma. (2010)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Atsuo Waki, Tetsuya Mori, Hiroshi Yoshii, Myungmi Oh, Tatsuya Asai, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi.
  • Journal Title: Nuclear Medicine and Biology. 37 Pages: 395-404
  • Peer Reviewed
• [Journal Article] Development of positron emission tomography imaging by 64Cu-labeled Fab for detecting ERC/mesothelin in a mesothelioma mouse model. (2010)
  • Author(s): Chisato Yoshida, Chizuru Sogawa, Atsushi Tsuji, Hitomi Sudo, Aya Sugyo, Tomoya Uehara, Okio Hino, Yukie Yoshii, Yasuhisa Fujibayashi, Toshimitsu Fukumura, Mitsuru Koizumi, Yasushi Arano, Tsuneo Saga.
  • Journal Title: Nuclear Medicine Communications. 31 Pages: 380-388
  • Peer Reviewed
• [Journal Article] Copper-64-diacetyl-bis (N^4-methylthiosemicarbazone) accumulates in rich regions of CD133^+ highly tumorigenic cells in mouse colon carcinoma (2010)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Atsuo Waki, Tetsuya Mori, Hiroshi Yoshii, Myungmi Oh, Tatsuya Asai, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi
  • Journal Title: Nuclear Medicine and Biology (In press)
  • Peer Reviewed
• [Journal Article] 癌の低酸素下エネルギー代謝戦略 (2009)
  • Author(s): 藤林靖久、古川高子、吉井幸恵
  • Journal Title: 医学のあゆみ 231 Nos.12, 13 Pages: 1150-1153
• [Journal Article] がん特異的酢酸代謝を標的としたがん診断および治療の可能性 (2009)
  • Author(s): 吉井幸恵、藤林靖久
  • Journal Title: ケミカルエンジニヤリング 54 Pages: 844-847
• [Presentation] Evaluation of 64Cu-ATSM for an internal radiotherapy agent : 64Cu-ATSM treatment reduces CD133+ highly tumorigenic cells and metastatic ability of tumors. (2010)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Tetsuya Mori, Hiroshi Yoshii, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi.
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting 2010
  • Place of Presentation: Salt Lake City, USA
• [Presentation] ミトコンドリアDNA欠損細胞(p0細胞)を用いたミトコンドリア機能不全と64Cu-ATSM 集積に関する検討. (2010)
  • Author(s): 吉井幸恵, 黒田悠生, 米田誠, 清野泰,森哲也, 吉井裕, 古川高子, 浅井竜哉, 岡沢秀彦, 藤林靖久
  • Organizer: 第5回日本分子イメージング学会
  • Place of Presentation: 大津
• [Presentation] Investigation on accumulation and therapeutic effect of ^<64>Cu-ATSM in mouse colon carcinoma model : the relation to CD133^+ highly tumorigenic cells (2010)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Tetsuya Mori, Hiroshi Yoshii, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi
  • Organizer: 2010 Pacifichem (The meeting of International Chemical Congress of Pacific Basin Societies)
  • Place of Presentation: Hawaii, USA
• [Presentation] Evaluation of ^<64>Cu-ATSM for an internal radiotherapy agent : ^<64>Cu-ATSM treatment reduces CD133^+ highly tumorigenic cells and metastatic ability of tumors (2010)
  • Author(s): Yukie Yoshii, Takako Furukawa, Yasushi Kiyono, Ryo Watanabe, Tetsuya Mori, Hiroshi Yoshii, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting 2010
  • Place of Presentation: Salt Lake City, USA
• [Presentation] ミトコンドリアDNA欠損細胞(ρ0細胞)を用いたミトコンドリア機能不全と^<64>Cu-ATSM集積に関する検討 (2010)
  • Author(s): 吉井幸恵、黒田悠生、米田誠、清野泰、森哲也、吉井裕、古川高子、浅井竜哉、岡沢秀彦、藤林靖久
  • Organizer: 第5回 日本分子イメージング学会
  • Place of Presentation: 大津
• [Presentation] がん幹細胞の低酸素・栄養飢餓生存性とがん幹細胞生存環境マーカーとしての^<64>Cu-ATSMの可能性 (2010)
  • Author(s): 鈴木佑哉、吉井幸恵、古川高子、清野泰、森哲也、吉井裕、浅井竜哉、岡沢秀彦、藤林靖久
  • Organizer: 第5回 日本分子イメージング学会
  • Place of Presentation: 大津
• [Presentation] がん幹細胞ニッチを標的としたイメージング・内用放射線治療の可能性 (2009)
  • Author(s): シンポジウム吉井幸恵, 古川高子, 藤林靖久
  • Organizer: 独立行政法人放射線医学総合研究所第9回重粒子医科学センターシンポジウム先端科学と社会の接点:粒子放射線生物研究の展開と先進治療
  • Place of Presentation: 千葉
• [Presentation] 64Cu-ATSM イメージング:低酸素・栄養飢餓とがん幹細胞との関係に関する検討 (2009)
  • Author(s): 吉井幸恵, 鈴木佑哉, 清野泰, 脇厚生, 渡辺亮, 森哲也, 吉井裕, 古川高子, 浅井竜哉, Michael J.Welch, 藤林靖久
  • Organizer: 第49回日本核医学会
  • Place of Presentation: 旭川
• [Presentation] 64Cu-ATSM imaging for cancer stem cell-rich regions : in vivo and in vitro characterization. (2009)
  • Author(s): Yukie Yoshii, Yasushi Kiyono, Atsuo Waki, Ryo Watanabe, Yuya Suzuki, Tetsuya Mori, Hiroshi Yoshii, Takako Furukawa, Tatsuya Asai, Takashi Kudo, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi.
  • Organizer: 2009 World Molecular Imaging Congress
  • Place of Presentation: Montreal, Canada
• [Presentation] Hypoxia imaging agent 64Cu-ATSM visualizes cancer stem cell-rich regions within tumors. (2009)
  • Author(s): Yukie Yoshii, Yasushi Kiyono, Ryo Watanabe, Atsuo Waki, Tetsuya Mori, Hiroshi Yoshii, Takako Furukawa, Myungmi Oh, Masato Kobayashi, Michael J.Welch, Yasuhisa Fujibayashi.
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting 2009
  • Place of Presentation: Toronto, Canada
• [Presentation] 64Cu-ATSM による腫瘍内がん幹細胞ニッチイメージングと内用放射線治療への応用 (2009)
  • Author(s): 吉井幸恵, 清野泰, 脇厚生, 渡辺亮, 森哲也, 吉井裕, 古川高子, 浅井竜哉, 工藤崇, 岡沢秀彦, Michael J.Welch, 藤林靖久
  • Organizer: 第4回日本分子イメージング学会
  • Place of Presentation: 東京
• [Presentation] がん幹細胞ニッチを標的としたイメージング・内用放射線治療の可能性 (2009)
  • Author(s): 吉井幸恵
  • Organizer: 独立行政法人放射線医学総合研究所第9回重粒子医科学センターシンポジウム
  • Place of Presentation: 千葉
• [Presentation] ^<64>Cu-ATSMイメージング:低酸素・栄養飢餓とがん幹細胞との関係に関する検討 (2009)
  • Author(s): 吉井幸恵、鈴木佑哉、清野泰、脇厚生、渡辺亮、森哲也、吉井裕、古川高子、浅井竜哉、Michael J.Welch、藤林靖久
  • Organizer: 第49回 日本核医学会
  • Place of Presentation: 旭川
• [Presentation] ^<64>Cu-ATSM imaging for cancer stem cell-rich regions : in vivo and in vitro characterization (2009)
  • Author(s): Yukie Yoshii, Yasushi Kiyono, Atsuo Waki, Ryo Watanabe, Yuya Suzuki, Tetsuya Mori, Hiroshi Yoshii, Takako Furukawa, Tatsuya Asai, Takashi Kudo, Hidehiko Okazawa, Michael J.Welch, Yasuhisa Fujibayashi
  • Organizer: 2009 World Molecular Imaging Congress
  • Place of Presentation: Montreal, Canada
• [Presentation] Hypoxia imaging agent ^<64>Cu-ATSM visualizes cancer stem cell-rich regions within tumors (2009)
  • Author(s): Yukie Yoshii, Yasushi Kiyono, Ryo Watanabe, Atsuo Waki, Tetsuya Mori, Hiroshi Yoshii, Takako Furukawa, Myungmi Oh, Masato Kobayashi, Michael J.Welch, Yasuhisa Fujibayashi
  • Organizer: The Society of Nuclear Medicine (SNM) annual meeting 2009
  • Place of Presentation: Toronto, Canada
• [Presentation] がん幹細胞の低酸素・栄養飢餓耐性:がん幹細胞生存環境マーカーとしての^<64>Cu-ATSMの有用性に関する基礎検討 (2009)
  • Author(s): 鈴木佑哉、吉井幸恵、清野泰、脇厚生、渡辺亮、森哲也、吉井裕、古川高子、浅井竜哉、工藤崇、岡沢秀彦、Michael J.Welch、藤林靖久
  • Organizer: 第4回日本分子イメージング学会
  • Place of Presentation: 東京
• [Presentation] ^<64>Cu-ATSMによる腫瘍内がん幹細胞ニッチイメージングと内用放射線治療への応用 (2009)
  • Author(s): 吉井幸恵、清野泰、脇厚生、渡辺亮、森哲也、吉井裕、古川高子、浅井竜哉、工藤崇、岡沢秀彦、Micllael J.Welch、藤林靖久
  • Organizer: 第4回日本分子イメージング学会
  • Place of Presentation: 東京
• [Presentation] 高再現性^<64>Niメッキ装置及び^<64>Cu自動分離精製装置の開発 (2009)
  • Author(s): 渡邉亮、吉井幸恵、森哲也、浅井竜哉、清野泰、中小路聡直、藤林靖久
  • Organizer: 第4回日本分子イメージング学会
  • Place of Presentation: 東京
• [Book] 放射線科学(がん幹細胞ニッチを標的としたイメージング・内用放射線治療の可能性).53(2) (2010)
  • Author(s): 井幸恵, 古川高子, 藤林靖久
  • Publisher: 独立行政法人 放射線医学総合研究所
• [Book] がん特異的酢酸代謝を標的としたがん診断および治療の可能性.(月刊ケミカルエンジニヤリング特集先端医療技術の開発と実用化).54(11) (2009)
  • Author(s): 吉井幸恵, 藤林靖久
  • Publisher: 株式会社 化学工業社
• [Remarks] ホームページ等
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