Predict of efficacy of GnRHagonist treatment for uterine leiomyoma using PET

• Project/Area Number: 21791177
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: CHINO Yoko 福井大学, 医学部附属病院, 医員 (40436845)
• Project Period (FY): 2009 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 核医学(PET を含む) / ホルモン療法 / FES-PET / 子宮筋腫 / GnRHagonist / PET / FES / FDG-PET

Research Abstract

We tried to predict the efficacy of GnRHagonist treatment foruterine leiomyoma by FES(16α-[18^F]fluoro-17β-estradiol)-PET and 18^F-FDG PET.3 of thirteen patients were markidly effective . Those FES-SUV value were higher thanother patients. The patient with high FES-SUV value is effective by GnRHagonist therapy.

Research Products

• [Journal Article] Localisation of phosphorylated mTOR expression is critical to tumour progression and outcomes in patients with endometrial cancer (2010)
  • Author(s): Y.Yoshida, T.Kurokawa, Y.Horiuchi, Y.Sawamura, A.Shinagawa, F.Kotsuji
  • Journal Title: Eur J Cancer Volume: 46(18) Pages: 3445-3452
  • URL: http://www.sciencedirect.com/science/journal/09598049
  • Peer Reviewed
• [Journal Article] 婦人科領域における PET/CT 検査 (2010)
  • Author(s): 吉田好雄、黒川哲司、澤村陽子、品川明子、 小辻文和、 辻川哲也、 岡沢秀彦
  • Journal Title: 産婦人科治療 Volume: 101(1) Pages: 25-33
  • URL: http://www.meteo-intergate.com/library/journal/journal-archive_af2sftye.php
• [Presentation] 16α-[18F]fluoro-17β-estradiol-PET を用いた子宮筋腫と子宮肉腫の新たな鑑別診断法 (2013)
  • Author(s): 黒川哲司、津吉秀昭、品川明子、知野陽子、 清野 泰、 岡沢秀彦、 吉田好雄
  • Organizer: 第1回婦人科がんバイオマーカー研究会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-02-16
• [Presentation] The combination of[18F]fluorodeoxy-glucose and 16α-[18F]fluoro-17β-estradiol positron emission tomography for identifying leiomyosarcoma in uterine smooth muscle tumors (2010)
  • Author(s): Y.Yoshida、 T.Kurokawa、 Y. Sawamura, A.Shinagawa、F.Kotsuji
  • Organizer: 2010 ASCO Annual Meeting
  • Place of Presentation: Chicago(USA)
• [Presentation] PET 検査を用いて子宮筋腫の GnRHa 療法の治療効果の予測は可能か (2010)
  • Author(s): 澤村陽子、吉田好雄、北野史子、品川明子、黒川哲司、小辻文和
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
• [Presentation] PET検査を用いて子宮筋腫のGnRHa療法の治療効果の予測は可能か (2010)
  • Author(s): 澤村陽子
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京都
• [Presentation] PET検査を用いたGnRHa療法の治療効果予測は可能か (2009)
  • Author(s): 澤村陽子
  • Organizer: 日本産科婦人科学会北日本連合地方部会学術講演会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-08-30
• [Presentation] PET 検査を用いた GnRHa 療法の治療効果予測は可能か (2009)
  • Author(s): 澤村陽子、吉田好雄、品川明子、黒川哲司、小辻文和、辻川哲也、工藤崇、岡沢秀彦、藤林康久
  • Organizer: 第57回日本産科婦人科学会北日本連合地方部会総会・学術講演会
  • Place of Presentation: 札幌市
• [Presentation] 子宮平滑筋腫瘍の評価における 18F-FDG PET検査と MRI 検査の比較検討 (2009)
  • Author(s): 吉田好雄、黒川哲司、品川明子、澤村陽子、後藤健次、小辻文和
  • Organizer: 第61回日本産科婦人科学会総会・学術講演会
  • Place of Presentation: 京都