Development of a molecular imaging probe for vulnerable plaque imaging
| Project/Area Number |
21791181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
OGAWA Mikako 浜松医科大学, メディカルフォトニクス研究センター, 准教授 (20344351)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 動脈硬化 / 分子イメージング / メタボリックシンドローム / 核医学イメージング / リポソーム / S / 蛍光イメージング |
|---|
| Research Abstract |
The rupture of atherosclerotic vulnerable plaques and the subsequent formation of thrombi are the main factors responsible for myocardial and cerebral infarctions. Macrophage infiltration is characteristics for atherosclerotic vulnerable plaques. Macrophages recognize phosphatidylserine(PS) that is exposed on the cell surface of the apoptotic cells to phagocytize these cells. In this study, we prepared PS liposomes for detection of vulnerable plaques. As a result, the atherosclerotic region was detected by this imaging probe.
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Report
(4 results)
Research Products
(41 results)
