Optical Imaging of Intratumoral HIF-1 activity to Optimize Treatment Regimens for Chemoradiotherapy

• Project/Area Number: 21791184
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: HARADA Hiroshi Kyoto University, 生命科学系キャリアパス形成ユニット, 講師 (80362531)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 放射線 / 腫瘍(がん) / 低酸素 / 微小環境 / 光イメージング / 悪性腫瘍(がん)

Research Abstract

Here, I and my colleagues performed a series of optical imaging experiments to visualize intratumoral HIF-1 activity, and optimized some combination of radiation with antitumor drugs, which could modulate HIF-1 activity, such as a VEGF neutralizing agent, bevacizumab, and a HIF-1 inhibitor, YC-1.
1. Optical imaging experiments showed that administration of a VEGF-neutralizing agent, bevacizumab, temporally induced vascular normalization and decreased hypoxic fraction in tumor xenografts 1 day after the treatment. When radiation treatment was given in this timing, the combined treatment significantly delayed tumor growth compared to radiation therapy alone.
2. We found that administration of a HIF-1 inhibitor, YC-1, suppressed radiation-induced activation of intratumoral HIF-1 activity, and then significantly delayed the growth of recurrent tumor after radiation therapy.

Research Products

• [Journal Article] AHR, a novel acute hypoxia-response sequence, drives reporter gene under hypoxia in vitro and in vivo. (2011)
  • Author(s): Cilek MZ, Hirohata S, Hatipoglu OF, Ogawa H, Miyoshi T, Inagaki J, Ohtsuki T, Harada H, Kamikawa S, Kusachi S, Ninomiya Y.
  • Journal Title: Cell Biol Int. 35 Pages: 1-8
• [Journal Article] Angiogenic and vasoprotective effects of adrenomedulin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice. (2011)
  • Author(s): Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H, Harada H, Yokoi H, Arai H, Itoh H, Nakao K, Takahashi R, Tomimoto H.
  • Journal Title: Stroke Volume: 42 Pages: 1122-1128
  • Peer Reviewed
• [Journal Article] AHR, a novel acute hypoxia-response sequence, drives reporter gene under hypoxia in vitro and in vivo. (2011)
  • Author(s): Cilek MZ, Hirohata S, Hatipoglu OF, Ogawa H, Miyoshi T, Inagaki J, Ohtsuki T, Harada H, Kamikawa S, Kusachi S, Ninomiya Y.
  • Journal Title: Cell Biol Int Volume: 35 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of indolyl chalcones as antitumor agents. (2010)
  • Author(s): Kumar D, Kumar NM, Akamatsu K, Kusaka E, Harada H, Ito T.
  • Journal Title: Bioorg Med Chem Lett. 20 Pages: 3916-3919
• [Journal Article] Indolequinone-rhodol conjugate as fluorescent probe for hypoxic cells : enzymatic activation and fluorescence properties. (2010)
  • Author(s): Komatsu H, Harada H, Tanabe K, Hiraoka M, Nishimoto S.
  • Journal Title: MedChemComm. 1 Pages: 50-53
• [Journal Article] Hypoxia-inducible factor 1 in Tumor Radioresistance. (2010)
  • Author(s): Harada H, Hiraoka M.
  • Journal Title: Current Signal Transduction Therapy. 5 Pages: 188-196
• [Journal Article] A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. (2010)
  • Author(s): Zhao T, Harada H, Teramura Y, Tanaka S, Itasaka S, Moriniibu A, Shinomiya K, Zhu Y, Hanaoka H, Iwata H, Saji H, Hiraoka M.
  • Journal Title: J Control Release. 144 Pages: 109-114
• [Journal Article] Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticle for enhanced tumor imaging in vivo : Synergistic effect of folate-receptor targeting and PEGylation. (2010)
  • Author(s): Miki K, Oride K, Inoue S, Kuramochi Y, Nayak RR, Matsuoka H, Harada H, Hiraoka M, Ohe K.
  • Journal Title: Biomaterials. 31 Pages: 934-942
• [Journal Article] Synthesis and biological evaluation of indolyl chalcones as antitumor agents. (2010)
  • Author(s): Kumar D, Kumar NM, Akamatsu K, Kusaka E, Harada H, Ito T.
  • Journal Title: Bioorg Med Chem Lett Volume: 20 Pages: 3916-3919
  • Peer Reviewed
• [Journal Article] Indolequinone-rhodol conjugate as fluorescent probe for hypoxic cells : enzymatic activation and fluorescence properties. (2010)
  • Author(s): Komatsu H, Harada H, Tanabe K, Hiraoka M, Nishimoto S.
  • Journal Title: MedChemComm Volume: 20 Pages: 50-53
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible factor 1 in Tumor Radioresistance (2010)
  • Author(s): Harada H, Hiraoka M.
  • Journal Title: Current Signal Transduction Therapy Volume: 5 Pages: 188-196
  • Peer Reviewed
• [Journal Article] A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells. (2010)
  • Author(s): Zhao T, Harada H, Teramura Y, Tanaka S, Itasaka S, Moriniibu A, Shinomiya K, Zhu Y, Hanaoka H, Iwata H, Saji H, Hiraoka M.
  • Journal Title: Journal of Controlled Release Volume: 144 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticle for enhanced tumor imaging in vivo : Synergistic effect of folate-receptor targeting and PEGylation. (2010)
  • Author(s): Miki K, Oride K, Inoue S, Kuramochi Y, Nayak RR, Matsuoka H, Harada H, Hiraoka M, Ohe K
  • Journal Title: Biomaterials Volume: 31 Pages: 934-942
  • Peer Reviewed
• [Journal Article] Monitoring of Hypoxia-selective Enzymatic Reduction of Indolequinone derivative by 19F-NMR. (2009)
  • Author(s): Tanabe K, Komatsu H, Harada H, Hiraoka M, Nishimoto S.
  • Journal Title: Photomedicine and Photobiology. 31 Pages: 31-32
• [Journal Article] The Akt/mTOR pathway assures the synthesis of HIF-1alpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors. (2009)
  • Author(s): Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M.
  • Journal Title: J.Biol.Chem. 284 Pages: 5332-5342
• [Journal Article] The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation. (2009)
  • Author(s): Wakamatsu T, Tanaka T, Oda S, Nishi K, Harada H, Daijo H, Takabuchi S, Fukuda K, Hirota K.
  • Journal Title: Euro J Pharm. 617 Pages: 17-22
• [Journal Article] Treatment regimen determines whether a HIF-1 inhibitor enhances or inhibits the effect of radiation therapy. (2009)
  • Author(s): Harada H, Itasaka S, Zhu Y, Zeng L, Xie X, Morinibu A, Shinomiya K, Hiraoka M.
  • Journal Title: Br J Cancer. 100 Pages: 747-757
  • NAID: 130005443407
• [Journal Article] The HIF-1-active microenvironment : An environmental target for cancer therapy. (2009)
  • Author(s): Kizaka-Kondoh S, Tanaka S, Harada H, Hiraoka M.
  • Journal Title: Adv Drug Deliv Rev. 61 Pages: 623-632
• [Journal Article] HIF imaging is useful to determine the timing of combining Bevacizumab with radiation. (2009)
  • Author(s): Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. 75 Pages: 463-467
• [Journal Article] Monitoring of biological one-electron reduction by 19F-NMR using hypoxia selective activation of a 19F-labeled indolequinone derivative. (2009)
  • Author(s): Tanabe K, Harada H, Narazaki M, Tanaka K, Inafuku K, Komatsu H, Ito T, Yamada H, Chujo Y, Matsuda T, Hiraoka M, Nishimoto S.
  • Journal Title: J Am Chem Soc. 131 Pages: 15982-15983
• [Journal Article] Ring-Opening Metathesis Polymerization-Based Synthesis of ICG-Containing Amphiphilic Triblock Copolymers for in Vivo Tumor Imaging. (2009)
  • Author(s): Miki K, Kuramochi Y, Oride K, Inoue S, Harada H, Hiraoka M, Ohe K.
  • Journal Title: Bioconjugate Chem. 20 Pages: 511-517
• [Journal Article] Radiolytic activation of cytarabine prodrug possessing 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics. (2009)
  • Author(s): Hirata N, Fujisawa Y, Tanabe K, Harada H, Hiraoka M, Nishimoto S.
  • Journal Title: Org Biomol Chem. 7 Pages: 651-654
  • NAID: 120001624118
• [Journal Article] Treatment regimen determines whether a HIF-1 inhibitor enhances or inhibits the effect of radiation therapy (2009)
  • Author(s): *Harada H, Itasaka S, Zhu Y, Zeng L, Xie X, Morinibu A, Shinomiya K, Hiraoka M
  • Journal Title: Br J Cancer 100 Pages: 747-757
  • NAID: 130005443407
  • Peer Reviewed
• [Journal Article] Monitoring of biological one-electron reduction by 19F-NMR using hypoxia selective activation of a 19F-labeled indolequinone derivative (2009)
  • Author(s): Tanabe K, Harada H, Narazaki M, Tanaka K, Inafuku K, Komatsu H, Ito T, Yamada H, Chujo Y, Matsuda T, Hiraoka M, Nishimoto S
  • Journal Title: J Am Chem Soc 131 Pages: 15982-15983
  • Peer Reviewed
• [Journal Article] HIF imaging is useful to determine the timing of combining Bevacizumab with radiation (2009)
  • Author(s): Ou G, Itasaka S, Zeng L, Shibuya K, Yi J, Harada H, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys 75 Pages: 463-467
  • Peer Reviewed
• [Journal Article] The HIF-1-active microenvironment : An environmental target for cancer therapy. (2009)
  • Author(s): Kizaka-Kondoh S, Tanaka S, Harada H, Hiraoka M
  • Journal Title: Adv Drug Deliv Rev 61 Pages: 623-632
  • Peer Reviewed
• [Journal Article] The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation (2009)
  • Author(s): Wakamatsu T, Tanaka T, Oda S, Nishi K, Harada H, Daijo H, Takabuchi S, Fukuda K, Hirota K
  • Journal Title: Euro J Pharm 617 Pages: 17-22
  • Peer Reviewed
• [Journal Article] The Akt/mTOR pathway assures the synthesis of HIF-lalpha protein in a glucose- and reoxygenation-dependent manner in irradiated tumors (2009)
  • Author(s): *Harada H, Itasaka S, Kizaka-Kondoh S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M
  • Journal Title: J.Biol.Chem 284 Pages: 5332-5342
  • Peer Reviewed
• [Journal Article] Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticle for enhanced tumor imaging in vivo : Synergistic effect of folate-receptor targeting and PEGylation (2009)
  • Author(s): Miki K, Oride K, Inoue S, Kuramochi Y, Nayak RR, Matsuoka H, Harada H, Hiraoka M, Ohe K
  • Journal Title: Biomaterials 31 Pages: 934-942
  • Peer Reviewed
• [Journal Article] Aigiogenic roles of adrenomodulin through VEGF induction.
  • Author(s): Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R.
  • Journal Title: NeuroReport. (in press)
• [Journal Article] Effective encapsulation of a new cationic gadolinium chelate into apoferitin and its evaluation as a MRI contrast agent.
  • Author(s): Makino A, Harada H, Okada T, Kimura H, Amano H, Saji H, Hiraoka M, Kimura S.
  • Journal Title: Nanomedicine. (in press)
• [Journal Article] Angiogenic and vasoprotective effects of adrenomedulin on prevention of cognitive decline after chronic cerebral hypoperfusion in mice.
  • Author(s): Maki T, Ihara M, Fujita Y, Nambu T, Miyashita K, Yamada M, Washida K, Nishio K, Ito H, Harada H, Yokoi H, Arai H, Itoh H, Nakao K, Takahashi R, Tomimoto H.
  • Journal Title: Stroke. (in press.)
• [Journal Article] Aigiogenic roles of adrenomodulin through VEGF induction.
  • Author(s): Maki T, Ihara M, Fujita Y, Nambu T, Harada H, Ito H, Nakao K, Tomimoto H, Takahashi R.
  • Journal Title: NeuroReport Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Effective encapsulation of a new cationic gadolinium chelate into apoferitin and its evaluation as a MRI contrast agent.
  • Author(s): Makino A, Harada H, Okada T, Kimura H, Amano H, Saji H, Hiraoka M, Kimura S.
  • Journal Title: Nanomedicine Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells
  • Author(s): Zhao T, *Harada H, Teramura Y, Tanaka S, Itasaka S, Moriniibu A, Shinomiya K, Zhu Y, Hanaoka H, Iwata H, Saji H, Hiraoka M
  • Journal Title: J Control Release (In press)
  • Peer Reviewed
• [Journal Article] Hypoxia-inducible factor 1 in Tumor Radioresistance
  • Author(s): *Harada H, Hiraoka M
  • Journal Title: Current Signal Transduction Therapy (In press)
  • Peer Reviewed
• [Presentation] 放射線生物学的視点で迫る「腫瘍低酸素・放射線抵抗性・がん再発の時空間関係」 (2011)
  • Author(s): 原田浩
  • Organizer: 第13回国際癌治療増感シンポジウム
  • Place of Presentation: 奈良県猿沢荘(招待講演)
  • Year and Date: 2011-02-11
• [Presentation] Tracking the dynamics of hypoxic tumor cells during tumor growth and after radiation therapy. (2011)
  • Author(s): Hiroshi Harada
  • Organizer: The 1st International Symposium for Molecular-targeting Radiation Therapy
  • Place of Presentation: 国立京都国際会館(招待講演)
  • Year and Date: 2011-02-03
• [Presentation] 放射線生物学的視点で迫る「腫瘍低酸素・放射線抵抗性・がん再発の時空間関係」 (2011)
  • Author(s): 原田浩
  • Organizer: 第13回国際癌治療増感シンポジウム
  • Place of Presentation: 奈良
• [Presentation] Tracking the dynamics of hypoxic tumor cells during tumor growth and after radiation therapy. (2011)
  • Author(s): Harada H.
  • Organizer: The 1st International Symposium for Molecular-targeting Radiation Therapy.
  • Place of Presentation: Kyoto.
• [Presentation] 光イメージングで迫る放射線治療後のがん再発メカニズム (2010)
  • Author(s): 原田浩
  • Organizer: 東北大学大学院医学研究科附属創生応用医学研究センター酸素医学コアセンターシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-19
• [Presentation] 光イメージングで迫る放射線治療後のがん再発メカニズム (2010)
  • Author(s): 原田浩
  • Organizer: 東北大学大学院医学研究科附属創生応用医学研究センター酸素医学コアセンターシンポジウム
  • Place of Presentation: 東北大学(招待講演)
  • Year and Date: 2010-11-19
• [Presentation] 高精度放射線治療法の確立を見据えた低酸素イメージングの方向性 (2010)
  • Author(s): 原田浩
  • Organizer: 第50回日本核医学会学術総会シンポジウム:放射線治療計画に貢献するPET/CTの展望
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2010-11-12
• [Presentation] 高精度放射線治療法の確立を見据えた低酸素イメージングの方向性 (2010)
  • Author(s): 原田浩
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮ソニックシティ(招待講演)
  • Year and Date: 2010-11-12
• [Presentation] 放射線治療後のがん局所再発における低酸素がん細胞の動態 (2010)
  • Author(s): 原田浩
  • Organizer: 第53回日本放射線影響学会
  • Place of Presentation: 京都テルサ
  • Year and Date: 2010-10-21
• [Presentation] 低酸素がん細胞の腫瘍内ダイナミクスと放射線治療抵抗性 (2010)
  • Author(s): 原田浩
  • Organizer: 第69回日本癌学会学術総会シンポジウム#17.
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] 低酸素がん細胞の腫瘍内ダイナミクスと放射線治療抵抗性 (2010)
  • Author(s): 原田浩
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪国際会議場(招待講演)
  • Year and Date: 2010-09-23
• [Presentation] 低酸素がん細胞の腫瘍内動態解析～がんの再発メカニズムの解明～ (2010)
  • Author(s): 原田浩
  • Organizer: 群馬大学Clinical Oncology Research研究会
  • Place of Presentation: 群馬大学
  • Year and Date: 2010-06-03
• [Presentation] 低酸素がん細胞の腫瘍内動態解析～がんの再発メカニズムの解明～ (2010)
  • Author(s): 原田浩
  • Organizer: 群馬大学Clinical Oncology Research研究会
  • Place of Presentation: 群馬大学(招待講演)
  • Year and Date: 2010-06-03
• [Presentation] Tracking the Dynamics of Hypoxic Tumor Cells during Local Tumor Recurrence after Radiation Therapy. (2010)
  • Author(s): Harada H.
  • Organizer: Fourth Military Medical University Seminar. Xi'an, China.
  • Year and Date: 2010-05-24
• [Presentation] Tracking the Dynamics of Hypoxic Tumor Cells during Local Tumor Recurrence after Radiation Therapy (2010)
  • Author(s): Hiroshi Harada
  • Organizer: China-Japan Bilateral Seminar on Radiation Medicine from Bench to Clinic.
  • Place of Presentation: The Fourth Military Medical niversity, Xi'an, China(招待講演)
  • Year and Date: 2010-05-24
• [Presentation] Imaging & Targeting of Hypoxic Tumor Cells (2010)
  • Author(s): Harada H
  • Organizer: Friedrich Miescher Institute Seminar
  • Place of Presentation: スイス・Friedrich Miescher Institute
  • Year and Date: 2010-03-16
• [Presentation] Reoxygenation, HIF-1, and Radioresistance. (2010)
  • Author(s): 原田浩
  • Organizer: 第12回癌治療増感研究シンポジウム
  • Year and Date: 2010-02-14
• [Presentation] Reoxygenation, HIF-1, and Radioresistance (2010)
  • Author(s): 原田浩
  • Organizer: 第12回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良・猿沢荘
  • Year and Date: 2010-02-14
• [Presentation] 光イメージングで迫る癌の放射線抵抗性機構 (2010)
  • Author(s): 原田浩
  • Organizer: 放射線生物若手勉強会
  • Place of Presentation: 千葉・放射線医学総合研究所
  • Year and Date: 2010-01-30
• [Presentation] 低酸素誘導性因子-1(HIF-1)による癌の放射線耐性機構の解明とその克服 (2009)
  • Author(s): 原田浩
  • Organizer: 第52回日本放射線影響学会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-13
• [Presentation] 低酸素誘導性因子-1(HIF-1)による癌の放射線耐性機構の解明とその克服 (2009)
  • Author(s): 原田浩
  • Organizer: 第52回日本放射線影響学会
  • Place of Presentation: 広島・広島市南区民文化センター
  • Year and Date: 2009-11-13
• [Presentation] Peri-necrotic tumor cells cause recurrence after radiotherapy through migration to tumor blood vessels. (2009)
  • Author(s): Harada H.
  • Organizer: International Symposium/Retreat, Kyoto University Global COE Program
  • Place of Presentation: Center for Frontier Medicine.
  • Year and Date: 2009-11-07
• [Presentation] Peri-necrotic tumor cells cause recurrence after radiotherapy through migration to tumor blood vessels (2009)
  • Author(s): Harada H
  • Organizer: International Symposium/Retreat, Kyoto University Global COE Program
  • Place of Presentation: 兵庫・淡路夢舞台
  • Year and Date: 2009-11-07
• [Presentation] Optical Imaging of Tumo Hypoxia, Cell Cycle, pH, and DNA double strand breaks to Analyze the Molecular Mechanism Underlying Tumor Radioresistance. (2009)
  • Author(s): Harada H.
  • Organizer: 3rd International Symposium on Nanomedicine.
  • Year and Date: 2009-11-04
• [Presentation] Optical Imaging of Tumor Hypoxia, Cell Cycle, pH, and DNA double strand breaks to Analyze the Molecular Mechanism Underlying Tumor Radioresistance (2009)
  • Author(s): Harada H
  • Organizer: 3^<rd> International Symposium on Nanomedicine
  • Place of Presentation: 岡崎コンファレンスセンター
  • Year and Date: 2009-11-04
• [Presentation] A Molecular Mechanism Underlying HIF-1-mediated Tumor Radioresistance. (2009)
  • Author(s): 原田浩
  • Organizer: 2009年度日本癌学会
  • Year and Date: 2009-10-03
• [Presentation] A Molecular Mechanism Underlying HIF-1-mediated Tumor Radioresistance (2009)
  • Author(s): 原田浩
  • Organizer: 68回 日本癌学会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2009-10-03
• [Presentation] Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance. (2009)
  • Author(s): Harada H.
  • Organizer: Two Interests Seminars at Gray Institute for Radiation Oncology & Biology, University of Oxford.
  • Place of Presentation: Oxford. United Kingdom.
  • Year and Date: 2009-09-25
• [Presentation] Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance (2009)
  • Author(s): Harada H
  • Organizer: Oxford University Seminar
  • Place of Presentation: 英国・オックスフォード大学Gray Institute
  • Year and Date: 2009-09-25
• [Presentation] Treatment regimen determines whether HIF-1 inhibitor enhances or inhibits therapeutic effect of radiation therapy (2009)
  • Author(s): Harada H, Hiraoka M
  • Organizer: ECCO & ESMO
  • Place of Presentation: ドイツ・Internationale Congress Centrum Berlin
  • Year and Date: 2009-09-22
• [Presentation] HIF-1によるがんの放射線抵抗性機構の解明 (2009)
  • Author(s): 原田浩、板坂聡、平岡真寛
  • Organizer: 第22回日本放射線腫瘍学会学術大会
  • Place of Presentation: 京都・京都国際会議場
  • Year and Date: 2009-09-17
• [Presentation] HIF-1の活性化を介した癌の巧妙な放射線耐性機構～in vivo光イメージングによるアプローチ～ (2009)
  • Author(s): 原田浩
  • Organizer: 第41回日本臨床分子形態学会
  • Place of Presentation: 神戸・神戸国際会議場
  • Year and Date: 2009-09-05
• [Presentation] がんの放射線耐性機構の解明と放射線治療への展開-HIF-1活性のイメージング研究に基づく提言- (2009)
  • Author(s): 原田浩
  • Organizer: 第39回放射線による制癌シンポジウム
  • Place of Presentation: 富山
  • Year and Date: 2009-07-11
• [Presentation] がんの放射線耐性機構の解明と放射線治療への展開 -HIF-1活性のイメージング研究に基づく提言- (2009)
  • Author(s): 原田浩
  • Organizer: 第39回 放射線による制癌シンポジウム
  • Place of Presentation: 富山・富山国際会議場
  • Year and Date: 2009-07-10
• [Presentation] HIF-1標的薬の二面性 ～放射線治療効果の増感と減弱～ (2009)
  • Author(s): 原田浩、板坂聡、森鳰章代、篠宮和美、平岡真寛
  • Organizer: 第13回日本がん分子標的治療学会
  • Place of Presentation: 徳島・ホテルクレメント徳島
  • Year and Date: 2009-06-25
• [Presentation] 放射線照射後に残存したピモニダゾール陽性細胞は腫瘍血管に遊走し、がんの再発源となる (2009)
  • Author(s): 原田浩、板坂聡、平岡真寛
  • Organizer: 第15回国際癌治療増感研究協会総会
  • Place of Presentation: 京都・メルパルク京都
  • Year and Date: 2009-06-20
• [Presentation] Tumor Hypoxia : A Microenvironmental Target in Cancer Therapy. (2009)
  • Author(s): Harada H.
  • Organizer: Asian Association of Radiation Research (AARR) Award Session in 2nd Asian Congress for Radiation Research (ACRR).
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2009-05-20
• [Presentation] Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance (2009)
  • Author(s): Harada H, Hiraoka M
  • Organizer: 2nd Asian Congress for Radiation Research
  • Place of Presentation: 韓国・ソウルCOEX
  • Year and Date: 2009-05-20
• [Presentation] Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance. (2009)
  • Author(s): Harada H.
  • Organizer: Symposium #10 (Tumor Microenvironment) in 2nd Asian Congress for Radiation Research (ACRR).
  • Place of Presentation: Seoul, Korea.
  • Year and Date: 2009-05-19
• [Presentation] Tumor Hypoxia : A Microenvironmental Target in Cancer Therapy (2009)
  • Author(s): Harada H, Hiraoka M
  • Organizer: 2nd Asian Congress for Radiation Research
  • Place of Presentation: 韓国・ソウルCOEX
  • Year and Date: 2009-05-19
• [Presentation] Identification of the source of Tumor recurrence after radiation therapy. (2009)
  • Author(s): Harada H.
  • Organizer: Radiation Oncology Seminar in Seoul National University, Seoul.
  • Year and Date: 2009-05-18
• [Presentation] HIF-1依存的に変色するがん細胞の樹立と腫瘍内HIF-1陽性細胞のイメージング (2009)
  • Author(s): 原田浩、板坂聡、平岡真寛
  • Organizer: 第4回日本分子イメージング学会
  • Place of Presentation: 東京・学術総合センター
  • Year and Date: 2009-05-14
• [Presentation] HIF-1の活性化を介した癌の巧妙な放射線耐性機構～in vivo光イメージングによるアプローチ～ (2009)
  • Author(s): 原田浩
  • Organizer: 第41回日本臨床分子形態学会
  • Place of Presentation: 神戸
• [Book] Target in Gene Therapy (2011)
  • Author(s): Hiroshi Harada
  • Publisher: Intech社(in pressのため不明)
• [Book] Pharmaceutical Perspectives of Cancer Therapeutics.Springer(Protein Transduction Domain-mediated Delivery of Anti-cancer Drugs and Proteins.Lu Y and Mahato RI)(eds). (2009)
  • Author(s): Harada H, Hiraoka M.
• [Book] 癌の臨床(がんの放射線抵抗性機構の解明と放射線治療への展開-HIF-1活性のイメージング研究に基づく提言),55 (2009)
  • Author(s): 原田浩、平岡真寛
• [Book] 放射線生物研究(2nd Asian Congress of Radiation Research(アジア放射線研究会議)に参加して-世界の放射線科学研究の動向分析-),44 (2009)
  • Author(s): 原田浩
• [Book] 放射線生物研究(Hypoxia-inducible Factor-1(HIF-1)による放射線治療後の腫瘍増殖亢進機構),44 (2009)
  • Author(s): 原田浩平岡真寛
• [Book] Targets in Gene Therapy.(Gene Therapy Strategy for Tumor Hypoxia.)
  • Author(s): Harada H.
  • Publisher: (in press.)
• [Book] からだと酸素の辞典(低酸素がん細胞の光学イメージング)
  • Author(s): 原田浩、平岡真寛
  • Publisher: (印刷中)
• [Remarks] ホームページ等
  • URL: http://www.cp.kyoto-u.ac.jp/Harada/
• [Remarks]
  • URL: http://www.cp.kyoto-u.ac.jp/Harada/index.html