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Sequential analysis of the acute hypoxia with the irradiation for prostate cancer

Research Project

Project/Area Number 21791193
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionOsaka University

Principal Investigator

ISOHASHI Fumiaki  Osaka University, 医学系研究科, 助教 (00448036)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords低酸素 / 前立腺癌 / 酸素分圧 / 経時的解析 / 放射線治療 / 小線源治療
Research Abstract

It is well known that intratumoral oxygen tension influenced radiation sensitivity. However, there is no report that sequential analysis of the acute hypoxia. With tissue oxygen pressure measuring assembly, we explored about a concrete implant method with the phantom making ourselves. We found a method that detains the tip of the electrode in a prostate with sheath introducer.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results)

  • [Journal Article] Concurrent weekly nedaplatin, external beam radiotherapy and high-dose-rate barchytherapy in patients with FIGO stage IIIb cervical cancer : A comparison with a cohort treated by radiotherapy alone2010

    • Author(s)
      馬淵誠士、礒橋文明
    • Journal Title

      Gynecol Obstet Invest

      Volume: 69 Pages: 224-232

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors for survival in patients with recurrent cervical cancer previously treated with radiotherapy2010

    • Author(s)
      馬淵誠士、礒橋文明
    • Journal Title

      Int J Gynecol Cancer

      Volume: 20 Pages: 834-840

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rectal dose and source strength of the high-dose-rate iridium-192 both affect late rectal bleeding after intracavitary radiation therapy for uterine cervical carcinoma2010

    • Author(s)
      礒橋文明
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 77 Pages: 758-764

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] What is the Optimum Minimum Segment Size Used in Step and Shoot IMRT for Prostate Cancer?2010

    • Author(s)
      高橋豊、礒橋文明
    • Journal Title

      J Radiat Res (Tokyo)

      Volume: 51 Pages: 543-552

    • NAID

      10026644341

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between dosimetric parameters and late rectal and urinary toxicities in patients treated with high-dose-rate brachytherapy used as monotherapy for prostate cancer.2009

    • Author(s)
      Konishi K, Yoshioka Y, Isohashi F, Sumida I, Kawaguchi Y, Kotsuma T. Adachi K, Morimoto M, Fukuda S, Inoue T.
    • Journal Title

      Int J Radiat Oncol Biol Phys 75(4)

      Pages: 1003-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-dose-rate interstitial brachytherapy for previously untreated cervical carcinoma2009

    • Author(s)
      礒橋文明
    • Journal Title

      Brachytherapy 8

      Pages: 234-239

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation Between Dosimetric Parameters and Late Rectal and UrinaryToxicities in Patients Treated With High-Dose-Rate Brachytherapy Used asMonotherapy for Prostate Cancer2009

    • Author(s)
      小西浩司
    • Journal Title

      Int J Radiat Oncol Biol Phys 75

      Pages: 1003-1007

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Verification of air-kerma strength of 125I seed for permanent prostate implants in Japan2009

    • Author(s)
      隅田伊織
    • Journal Title

      Int.J Clin Oncol 14

      Pages: 525-528

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative concurrent nedaplatin-based chemoradiotherapy improves survival in early-stage cervical cancer patients with adverse risk factors2009

    • Author(s)
      馬淵誠士
    • Journal Title

      Gynecol Oncol 115

      Pages: 482-487

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monotherapeutic high-dose-rate brachytherapy for prostate cancer : five-year results of an extreme hypofractionation regimen with 54 Gy in nine fractions.

    • Author(s)
      Yoshioka Y, Konishi K, Sumida I, Takahashi Y, Isohashi F, Ogata T, Koizumi M, Yamazaki H, Nonomura N, Okuyama A, Inoue T.
    • Journal Title

      Int J Radiat Oncol Biol Phys in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 子宮頸癌術後照射における小腸に対する照射体積と急性・亜急性期の腸炎発生との関係2010

    • Author(s)
      礒橋文明
    • Organizer
      日本放射線腫瘍学会
    • Place of Presentation
      千葉
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮頸癌に対する高線量率組織内照射2010

    • Author(s)
      礒橋文明
    • Organizer
      日本婦人科腫瘍学会
    • Place of Presentation
      筑波(招待講演)
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Monotherapeutic high-dose-rate brachytherapy for prostate cancer : 15 years experience of Osaka University.2010

    • Author(s)
      Konishi Y, Yoshioka Y, Sumida I, Takahashi Y, Ogata T, Isohashi F, Koizumi M, Inoue T.
    • Organizer
      52^<nd> annual meeting of the American Society for Radiation Oncology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 再発子宮頸癌に対する高線量率組織内照射2009

    • Author(s)
      礒橋文明
    • Organizer
      第22回日本放射線腫瘍学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低酸素下のIGF刺激は小胞体ストレス反応を通して膵臓癌細胞の放射線感受性を上昇させる2009

    • Author(s)
      礒橋文明
    • Organizer
      第68回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2009-04-19
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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