Cryoablation for lung tumors : optimal freeze-thaw sequence and clinical application

• Project/Area Number: 21791214
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: INOUE Masanori 慶應義塾大学, 医学部, 助教 (30338157)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: インターベンショナルラジオロジー(IVR) / 凍結治療 / 肺腫瘍 / IVR / 放射線科学 / 癌 / インターベンショナルラジオロジー

Research Abstract

1) We drew the isothermal curves by measuring the temperature of a normal porcine lung in vivo based on the same freeze-thaw cycles as actual cryoablation for malignant lung tumors. As a result of the analysis with the isothermal curve and the freezing function, the frozen area of the iceball was larger in the second cycle than in the first cycle. It is supposed that bleeding in the first freeze-thaw cycle increases the thermal diffusivity around the cryoprobe and it is enabled to freeze a greater area in the second freezing. 2) The correlation between the isothermal curves and histologic findings was examined. These findings were also compared with the clinical findings on computed tomography(CT). The present study has demonstrated that the less than-20℃zone corresponds to the central solid zone on CT.

Research Products

• [Journal Article] Prediction of the critical thermal zone during pulmonary cryoablation on computed tomography from correlated experimental and clinical findings (2012)
  • Author(s): Hashimoto K, Izumi Y, Yamauchi Y, Yashiro H, Inoue M, et al
  • Journal Title: J Thorac Cardiovasc Surg Volume: 13
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation of lung tumors : feasibility and safety (2012)
  • Author(s): Inoue M, Nakatuska S, Yasho H, et al
  • Journal Title: J Vasc Interv Radiol Volume: 23(3) Pages: 303-5
  • Peer Reviewed
• [Journal Article] Percutaneous Cryoablation for the Treatment of Medically Inoperable Stage I Non-Small Cell Lung Cancer (2012)
  • Author(s): Yamauchi Y, Izumi Y, Hashimoto K, Yashiro H, Inoue M, et al
  • Journal Title: PLoS One Volume: 7(3)
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation of lung tumors: Feasibility and safety (2012)
  • Author(s): Inoue M, Nakatsuka S, et al
  • Journal Title: Journal of Vascular and Interventional Radiology Volume: 23 Issue: 3 Pages: 295
  • DOI: 10.1016/j.jvir.2011.11.019
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation for the treatment of medically inoperable Stage I non-small cell lung cancer (2012)
  • Author(s): Yamauchi Y, Izumi Y, Hashimoto K, Yashiro H, Inoue M, et al
  • Journal Title: PLoS ONE Volume: 7 Issue: 3 Pages: e33223-e33223
  • DOI: 10.1371/journal.pone.0033223
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation of pulmonary metastases from colorectal cancer (2011)
  • Author(s): Yamauchi Y, Izumi Y, Kawamura M, Nakatsuka S, Yashiro H, Tsukada N, Inoue M, et al
  • Journal Title: PLoS One Volume: 6(11)
  • Peer Reviewed
• [Journal Article] Percutaneous cryoablation of pulmonary metastases from colorectal cancer (2011)
  • Author(s): Yamauchi Y, Izumi Y, Kawamura M, Nakatsuka S, Yashiro H, Tsukada N, Inoue M, et al
  • Journal Title: PLoS ONE Volume: 6 Issue: 11 Pages: e27086-e27086
  • DOI: 10.1371/journal.pone.0027086
  • Peer Reviewed
• [Journal Article] On freeze-thaw sequence of vital organ of assuming the cryoablation for malignant lung tumors by using cryoprobe as heat source (2010)
  • Author(s): Nakatsuka S, Yashiro H, Inoue M, et al
  • Journal Title: Cryobiology Volume: 61(3) Pages: 317-26
  • Peer Reviewed
• [Journal Article] On freeze-thaw sequence of vital organ of assuming the cryoablation for malignant lung tumors by using cryoprobe as heat source. (2010)
  • Author(s): Nakatuska S, Yashiro H, Inoue M., et al
  • Journal Title: Cryobiology Volume: 61 Pages: 317-326
  • Peer Reviewed
• [Journal Article] 基本に立ち戻って親カテーテル/ガイディングシステムを考えるHLH型カテーテル (2009)
  • Author(s): 井上政則, 橋本統
  • Journal Title: Rad Fan 7 Pages: 60-61
• [Presentation] 凍結治療の現状と未来 (2011)
  • Author(s): 井上政則
  • Organizer: 第13回放射線科IVRセミナー
  • Place of Presentation: 大阪大学医学部臨床研究棟(大阪府)(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Does "vessel guard(VG) technique" improve local control rate in cryoablation for lung tumors? (2011)
  • Author(s): M. Inoue, S. Nakatsuka, H. Yashiro, et al
  • Organizer: CIRSE(Cardiovascular and Interventional Radiological Society of Europe)
  • Place of Presentation: Munich, Germany
• [Presentation] Diagnostic yield of 16-G core needle biopsy under the three-slice CT fluoroscopic guidance of paraaortic lesions : how many specimens is enough to diagnose? (2010)
  • Author(s): M Inoue, S Nakatuska, N Ito., et al
  • Organizer: CIRSE 2010
  • Place of Presentation: Valencia, Spain
• [Presentation] Thawing until temperature reaches a plateau is required for maximum frozen volume in lung cryoablation (2009)
  • Author(s): M. Inoue, S. Nakatsuka, H. Yashiro, et al
  • Organizer: CIRSE(Cardiovascular and Interventional Radiological Society of Europe)
  • Place of Presentation: Lisbon, Portugal
• [Presentation] Thawing until temperature reaches a plateau is required for maximum frozen volume in lung cryoablation (2009)
  • Author(s): M Inoue, S Nakatsuka, et al.
  • Organizer: CIRSE (Cardiovascular and Interventional Radiological Society of Europe)2009
  • Place of Presentation: Lisbon, Portugal