Synthesis of Br-76 labeled MBBG and applications to tumor imaging with PET
| Project/Area Number |
21791227
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Japan Atomic Energy Agency |
|---|
Principal Investigator |
WATANABE Shigeki Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究員 (10450305)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HANAOKA Hirofumi 群馬大学, 大学院・医学系研究科, 助教 (50361390)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | Br-76 / PET / イメージング / 褐色細胞腫 / 神経内分泌腫瘍 / RI内用療法 |
|---|
| Research Abstract |
In this study, we prepared positron emitter ^<76>Br labeled Meta-bromobenzylguanidine (^<76>Br-MBBG), and investigated the utilities as a PET reagent. 76Br-MBBG was administrated to pheochromocytoma bearing mice, and displayed higher accumulation in tumor at 3 hours after administration. In PET imaging studies, 76Br-MBBG depicted pheochromocytoma clearly. These results strongly indicated that 76Br-MBBG is useful PET reagent for pheochromocytoma.
|
Report
(3 results)
Research Products
(16 results)
