Development of stabilized neuroreceptor concentration imaging method based on pattern recognition for kinetic analysis in PET

• Project/Area Number: 21791233
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Kitasato University (2010); National Institute of Radiological Sciences (2009)
• Principal Investigator: SAKAGUCHI Kazuya Kitasato University, 医療衛生学部, 講師 (40521175)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 核医学 / PET / 薬物動態解析 / 神経受容体濃度測定 / 神経受容体

Research Abstract

In neuroreceptor concentration measuring with PET, this study proposed developing a stabilized kinetic imaging algorithm which is based on a novel voxel-based kinetic parameter estimation method with high accuracy and high robustness. The proposed method estimated proportionality constant during transient equilibrium condition. The method restricted to reduce the number of data points, and it was not enough to use in clinical study. However, this study indicates that the method has an ability to improve using points of data from before equilibrium.

Research Products

• [Journal Article] パラメトリック固有空間を利用したPET動態データの雑音除去 (2010)
  • Author(s): 星野直輝, 本谷秀堅, 坂口和也, 坂田宗之, 石渡喜一, 木村裕一
  • Journal Title: 日本医用画像工学会論文誌 Vol.28, No.5 Pages: 362-370
  • NAID: 130000446944
  • Peer Reviewed
• [Journal Article] Imaging of I2-imidazoline receptors by small-animal PET using 2-(3-fluoro-[4-^<11>C]tolyl)-4,5-dihydro-1H-imidazole([^<11>C]FTIMD). (2010)
  • Author(s): K.Kawamura, M.Naganawa, F.Konno, J.Yui, H.Wakizaka, T.Yamasaki, K.Yanamoto, A.Hatori, M.Takei, Y.Yoshida, K.Sakaguchi, T.Fukumura, Y.Kimura MR.Zhang.
  • Journal Title: Nucl Med Biol Vol.37, No.5 Pages: 625-635
  • Peer Reviewed
• [Journal Article] PETにおける神経受容体機能計測のための動態解析 (2009)
  • Author(s): 坂口和也, 木村裕一
  • Journal Title: 日本医用画像工学会論文誌 Vol.27, No.4 Pages: 286-291
• [Journal Article] PETにおける脳神経受容体機能計測のための動態解析 (2009)
  • Author(s): 坂口和也, 木村裕一
  • Journal Title: 日本医用画像工学会誌 27 Pages: 286-291
  • NAID: 10026248132
• [Presentation] PET神経受容体濃度画像作成におけるグラフ解析法のための雑音低減処理法の構築 (2011)
  • Author(s): 坂口和也
  • Organizer: 第101回日本医学物理学会学術大会
  • Place of Presentation: (発表確定 Web開催(震災の為、横浜開催中止))
• [Presentation] パラメトリック固有空間を利用したPET動態データの雑音除去 (2010)
  • Author(s): 星野直輝, 本谷秀堅, 坂口和也, 坂田宗之, 石渡喜一, 木村裕一
  • Organizer: 日本医用画像工学会大会2010
  • Place of Presentation: 伊勢原
• [Presentation] PET受容体解析法MA1の計測データの誤差分布特性に基づく改善の試み (2010)
  • Author(s): 星野直輝, 本谷秀堅, 長縄美香, 坂口和也, 坂田宗之, 石渡喜一, 木村裕一
  • Organizer: 電子情報通信学会医用画像研究会MI2009-76, pp.285-290
  • Place of Presentation: 那覇
• [Presentation] 定量PET機能画像におけるχ2検定によるグラフ解析法開始時刻の決定 (2010)
  • Author(s): 大柿宏人, 坂口和也, 菅幹生, 木村裕一
  • Organizer: 電子情報通信学会医用画像研究会,MI2009-75, pp.1-6
  • Place of Presentation: 那覇
• [Presentation] Logan法における主成分分析を用いた雑音低減処理の評価 (2009)
  • Author(s): 坂口和也, 他
  • Organizer: 日本核医学会総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-10-02
• [Presentation] Logan法における主成分分析を用いた雑音低減処理法の評価 (2009)
  • Author(s): 坂口和也, 長縄美香, 坂田宗之, 志田原美保, 関千江, 石渡喜一, 木村裕一
  • Organizer: 第49回日本核医学会学術総会
  • Place of Presentation: 旭川
• [Presentation] Unbiased Logan Graphical Analysis using the Renormalization Method. (2009)
  • Author(s): H.Hontani, N.Hoshino, M.Naganawa, K.Sakaguchi, M.Sakata, K.Ishiwata, Y.Kimura.
  • Organizer: Brain'09 and Brain PET'09
  • Place of Presentation: Chicago, USA.
• [Presentation] A Noise Reduction Method for Graphical Analysis with KL-Expansion during Transient Equilibrium Condition. (2009)
  • Author(s): K.Sakaguchi, M.Naganawa, M.Sakata, M.Shidahara, C.Seki, K.Ishiwata, Y.Kimura.
  • Organizer: Brain'09 and Brain PET'09
  • Place of Presentation: Chicago, USA.
• [Presentation] A Noise Reduction Method for Graphical Analysis with KL-expansion during Transient Equilibrium Condition (2009)
  • Author(s): Kazuya Sakaguchi, et al
  • Organizer: Brain'09 and Brain PET'09
  • Place of Presentation: Chicago, USA