Effect of carbon-ion beams for highly metastatic potentials of mouse malignant melanomas
| Project/Area Number |
21791234
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
MATSUMOTO Yoshitaka 独立行政法人放射線医学総合研究所, 重粒子医科学センター, 研究員 (70510395)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 粒子線治療 / 重粒子線 / 炭素線 / 転移 / 悪性黒色腫 / RBE / 浸潤能 / 遊走能 / 接着能 |
|---|
| Research Abstract |
In this study, the effects of the carbon-ion beam(C-ions) and photon beam to the cytotoxic affects and metastasis abilities of highly metastatic cancer were investigated using cell and animal experiments. C-ions showed superior effects to not only cell death but also inhibition of cell migration, invasion and adhesion abilities concerned with metastasis than photons. Additionally, the C-ions significantly suppressed the number of lung metastasis compared with photons in animal experiment, and the effect was remarkable even when compared with biological iso-effective dose on tumor cell survival. It was suggested that high-LET radiation, such as C-ions, would suppress the metastasis significantly compared with photon beams, such as a gamma ray and X-rays.
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Report
(4 results)
Research Products
(35 results)
