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Fundamental experiments for a quantitative myocardial blood flow measurement in 3D-PET

Research Project

Project/Area Number 21791237
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences (2011)
National Cardiovascular Center Research Institute (2009-2010)

Principal Investigator

HIRANO Yoshiyuki  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 博士研究員 (00423129)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords3D-PET / 散乱線補正 / 心筋血流 / モンテカルロシミュレーション / 陽電子断層撮影装置 / モンテカルロ・シミュレーション / 数値人体モデル / 心臓PET / 心筋バイアビリティ / 視野外放射能 / 定量検査 / O-15 PET / 散乱同時計数 / 偶発同時計数 / 0-15 PET
Research Abstract

Accuracy of quantitative myocardial blood flow(MBF) measurements using 3D-PET depends on activity distribution, especially outside filed-of-view(FOV) distribution. We investigated the influence on quantification of MBF by fundamental phantom experiments and a sophisticated Monte Carlo simulation. The effects of outside FOV activity were not critical for quantification of MBF. Especially, a MBF measurement by O-15 water was less insensitive to scatter originated from outside FOV activity.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (8 results) Book (3 results)

  • [Journal Article] Monte Carlo simulation of scintillation photons for the design of a high-resolution SPECT detector dedicated to human brain2012

    • Author(s)
      Yoshiyuki Hirano, Tsutomu Zeniya and Hidehiro Iida
    • Journal Title

      Annals of Nuclear Medicine

      Volume: Vol.26, No.3 Issue: 3 Pages: 214-221

    • DOI

      10.1007/s12149-011-0561-4

    • NAID

      10030623783

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Monte Carlo estimation of effects of activity outside of filed of view in O-15 cardiac 3D-PET2010

    • Author(s)
      Y. Hirano, K. Koshino, and H, Iida
    • Journal Title

      IEEE Nuclear Science Symposium Conference Record

      Pages: 2535-2538

    • Related Report
      2011 Final Research Report
  • [Journal Article] Fundamental Phantom Experiments and Simulations Aimed at Quantification of Myocardial Blood Flow Using 3-D PET2009

    • Author(s)
      Yoshiyuki Hirano
    • Journal Title

      IEEE Nuclear Science Symposium Conference Record

      Pages: 3353-3356

    • Related Report
      2010 Annual Research Report
  • [Presentation] O-15心筋血流定量検査における視野外放射能による定量値への影響-モンテカルロシミュレーションによる評価-2010

    • Author(s)
      平野祥之
    • Organizer
      第50回日本核医学学術総会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] O-15心筋血流定量検査における視野外放射能による定量値への影響-モンテカルロシミュレーションによる評価-2010

    • Author(s)
      平野祥之、越野一博、飯田秀博
    • Organizer
      第50回日本核医学学術総会
    • Place of Presentation
      埼玉大宮市、大宮ソニックシティ
    • Year and Date
      2010-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] A Monte Carlo estimation of quantitative myocardial blood flow in 3D-PET2010

    • Author(s)
      Y. Hirano, K. Koshino, and H, Iida
    • Organizer
      SNM
    • Place of Presentation
      Salt Lake City USA
    • Year and Date
      2010-06-08
    • Related Report
      2011 Final Research Report
  • [Presentation] A Monte Carlo estimation of quantitative myocardial blood flow in 3D-PET2010

    • Author(s)
      Yoshiyuki Hirano
    • Organizer
      SNM
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2010-06-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fundamental Phantom Experiments and Simulations Aimed at Quantification of Myocardial Blood Flow Using 3-D PET2009

    • Author(s)
      Y. Hirano, H. Watabe, K. Koshino, and H, Iida
    • Organizer
      IEEE Medical Imaging Conference
    • Place of Presentation
      Orlando USA
    • Year and Date
      2009-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 3D-心臓PETにおける散乱線および偶発同時計数の影響2009

    • Author(s)
      平野祥之、越野一博、飯田秀博
    • Organizer
      第49回日本核医学学術総会
    • Place of Presentation
      旭川市民文化会館・旭川グランドホテル
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 3D-心臓PETにおける散乱線および偶発同時計数の影響2009

    • Author(s)
      平野祥之
    • Organizer
      第49回日本核医学学会学術総会
    • Place of Presentation
      旭川グランドホテル
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] PETにおける散乱線および偶発同時計数による心筋血流の定量評価への影響2008

    • Author(s)
      平野祥之、渡部浩司、石田良雄、木曽啓祐、飯田秀博
    • Organizer
      第48回日本核医学学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2008-10-26
    • Related Report
      2011 Final Research Report
  • [Book] 遺伝子医学MOOK18号1章10節を担当:創薬研究への分子イメージング応用分子イメージング臨床用PET装置2011

    • Author(s)
      平野祥之、飯田秀博
    • Publisher
      メディカルドゥ
    • Related Report
      2011 Final Research Report
  • [Book] Applications of Monte Carlo Methods in Biology, Medicine and Other Fields of Science, Chapter 5 : Applications to Development of PET/SPECT System by Use of Geant42011

    • Author(s)
      Yoshiyuki Hirano, 他68名
    • Publisher
      InTECH
    • Related Report
      2011 Final Research Report
  • [Book] Theory and Applications of Monte Carlo Simulations2011

    • Author(s)
      Yoshiyuki Hirano
    • Total Pages
      18
    • Publisher
      InTECH
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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