Molecular oncological study on lung cancer among atomic-bomb survivors

• Project/Area Number: 21791238
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: 放射線影響研究所 (2011); Radiation Effects Research Foundation (2009-2010)
• Principal Investigator: TAGA Masataka 放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (70359462)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 放射線 / 肺がん / 遺伝子変異 / メチル化 / LINE1 / Alu / LINE-1

Research Abstract

Risk of lung cancer among atomic-bomb(A-bomb) survivors remains high even now, more than 60 years after the bombings. However, the molecular mechanisms behind how radiation exposure influences the development of lung cancer have long remained unclear. Therefore, this study aimed to investigate the molecular oncological characteristics of lung cancer among A-bomb survivors by analyzing molecular alterations associated with lung carcinogenesis. In combination with our preliminary study, results obtained from this study suggest the possibility that molecular alterations such as frequencies of certain gene mutations and the types and DNA methylation may be associated with radiation exposure.

Research Products

• [Journal Article] Improved method for analysis of RNA present in long-term preserved thyroid cancer tissue of atomic bomb survivors (2010)
  • Author(s): Hamatani K, Eguchi H, Mukai M, Koyama K, Taga M, Ito R, Hayashi Y, Nakachi K
  • Journal Title: Thyroid Volume: 20(1) Pages: 43-9
  • Peer Reviewed
• [Journal Article] Improved method for analysis of RNA present in long-term preserved thyroid cancer tissue of atomic bomb survivors (2010)
  • Author(s): Hamatani, K.
  • Journal Title: Thyroid 20 Pages: 43-49
  • Peer Reviewed
• [Journal Article] EGFR somatic mutations in lung tumors : Radon exposure and passive-smoking in former-and never-smoking U. S. women
  • Author(s): Taga M, Mechanic LE, Hagiwara N, Vahakangas KH, Bennett WP, Alavanja MC, Welsh JA, Khan MA, Lee A, Diasio R, Edell E, Bungum A, Jang JS, Yang P, Jen J, Harris CC
  • Journal Title: Cancer Epidemiology, Biomarkers & Prevention Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] EGFR somatic mutations in lung tumors : Radon exposure and passive-smoking in former- and never-smoking U.S.women
  • Author(s): Taga M
  • Journal Title: Cancer Epidemiology, Biomarkers & Prevention Volume: (印刷中)
  • Peer Reviewed
• [Presentation] 原爆被爆者で発生した非小細胞肺がんにおけるLINE1のDNAメチル化 (2010)
  • Author(s): 多賀正尊、伊藤玲子、丹羽保晴、三角宗近、中地敬、安井弥、楠洋一郎、濱谷清裕
  • Organizer: 日本放射線影響学会第53回大会
  • Place of Presentation: 京都
• [Presentation] 原爆被爆者で発生した非小細胞肺がんにおけるがん関連遺伝子のDNAメチル化 (2009)
  • Author(s): 多賀正尊、伊藤玲子、三角宗近、中地敬、安井弥、濱谷清裕
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
• [Remarks]
  • URL: http://www.rerf.jp/library/rr/rr0807.htm