Developing a novel therapy targeting graft inflammation in pediatric organ transplantation.
Project/Area Number |
21791241
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General surgery
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Research Institution | University of Tsukuba |
Principal Investigator |
FUJISHIRO Jun University of Tsukuba, 大学院・人間総合科学研究科, 講師 (60528438)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 虚血再潅流障害 / グラフト炎症 / 免疫抑制剤 / 拒絶反応 / 臓器保存 / 虚血再潅流障 / 臓器移植 / エリスロポイエチン |
Research Abstract |
Graft manipulation, ischemia/reperfusion injury and acute rejection all initiate a severe cellular and molecular inflammation in graft organ, which would impair short- and long-term graft function. In this study, I showed that 1) non-specific and T cell mediated inflammation process occurred in graft muscle layer just after reperfusion in rat small bowel transplantation, tacrolimus and sirolimus both reduced above-mentioned complex inflammation and improved graft motility and 2)long-acting erythropoietion analog darbepoetion had promising organ-protecting effect in rat liver ischemia/reperfusion injury model.
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Report
(3 results)
Research Products
(2 results)