Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Research Abstract |
Graft manipulation, ischemia/reperfusion injury and acute rejection all initiate a severe cellular and molecular inflammation in graft organ, which would impair short- and long-term graft function. In this study, I showed that 1) non-specific and T cell mediated inflammation process occurred in graft muscle layer just after reperfusion in rat small bowel transplantation, tacrolimus and sirolimus both reduced above-mentioned complex inflammation and improved graft motility and 2)long-acting erythropoietion analog darbepoetion had promising organ-protecting effect in rat liver ischemia/reperfusion injury model.
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