Development of cancer immunotherapy using dendritic cells genetically modified to express Interleukin-23

• Project/Area Number: 21791244
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: The University of Tokyo
• Principal Investigator: SATO Marimo The University of Tokyo, 医科学研究所, 助教 (50401253)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: インターロイキン-23 / 樹状細胞 / アデノウィルスベクター / 癌免疫療法 / 遺伝子治療 / インターロイキン23 / がん免疫療法

Research Abstract

I investigated whether bone marrow- derived dendritic cells (BM-DCs) adenovirally transduced with genes encoding murine IL-23 have therapeutic benefits for antitumor immunotherapy. This strategy designed to deliver genetically modified DCs to tumor sites is associated with systemic and therapeutic antitumor immunity and could be an alternative approach to those using delivery of DCs loaded with defined tumor antigens. These results support the clinical development of IL-23 gene-modified DCs in patients with cancer.

Research Products

• [Journal Article] Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100-derived epitope peptide restricted to HLA-A*2402. (2010)
  • Author(s): Toshiyuki Baba, Marimo Sato-Matsushita, Akira Kanamoto, Akihiko Itoh, Naoki Oyaizu, Yusuke Inoue, Yutaka Kawakami, Hideaki Tahara
  • Journal Title: Journal of Translational Medicine 8 Pages: 84-84
• [Journal Article] Phase I clinical trial of the vaccination for the patients with metastatic melanoma using gp100-derived epitope peptide restricted to HLA-A*2402 (2010)
  • Author(s): Toshiyuki Baba, Marimo Sato-Matsushita (Contributed equally), Akira Kanamoto, Akihiko Itoh, Naoki Oyaizu, Yusuke Inoue, Yutaka Kawakami, Hideaki Tahara
  • Journal Title: Journal of Translational Medicine Volume: 84 Pages: 8-20
  • Peer Reviewed
• [Journal Article] Emerging concepts in biomarker discovery ; The US-Japan Workshop on Immunological Molecular Markers in Oncology. (2009)
  • Author(s): Hideaki Tahara, Marimo Sato, Magdalena Thurin, Ena Wang, Lisa H Butterfield, Mary L Disis, Bernard A Fox, Peter P Lee, Jon M Wigginton, Stefan Ambs, Yasunori Akutsu, Damien Chaussabel, Yuichiro Doki, Yoshihiko Hirohashi, Kohzoh Imai, James Jacobson, Masahisa Jinushi, Akira Kanamoto, Mohammed Kashani-Sabet, Kazunori Kato, Yutaka Kawakami, John M Kirkwood, Michael T Lotze, Hisahiro Matsubara, Kiminori Nakamura, Hiroyoshi Nishikawa, Zoltan Pos, Raj Puri, Antoni Ribas, Noriyuki Sato, Hiroshi Shiku, Howard Streicher, David F Stroncek, Hiroya Takeuchi, Minoru Toyota, Hisashi Wada, Tomonori Yaguchi, Yingdong Zhao, Francesco M Marincola
  • Journal Title: J Translational Med. 7 Pages: 45-45
• [Journal Article] Milk Fat Globule EGF-8 Blockade Triggers Tumor Destruction through Coordinated Cell-Autonomous and Immune-Mediated Mechanisms. (2009)
  • Author(s): Masahisa Jinushi, Marimo Sato, Akira Kanamoto, Akihiko Itoh1, Shigenori Nagai, Shigeo Koyasu, Glenn Dranoff, Hideaki Tahara
  • Journal Title: J Exp Med 206 Pages: 1317-1326
• [Journal Article] Milk Fat Globule EGF-8 Blockade Triggers Tumor Destruction through Coordinated Cell-Autonomous and Immune-Mediated Mechanisms (2009)
  • Author(s): Masahisa Jinushi, Marimo Sato, Akira Kanamoto, Akihiko Itoh, Shigenori Nagai, Shigeo Koyasu, Glenn Dranoff, Hideaki Tahara
  • Journal Title: Journal of Experimental Medicine 206 Pages: 1317-1326
  • Peer Reviewed
• [Journal Article] Emerging concepts in biomarker discovery ; The US-Japan Workshop on Immunological Molecular Markers in Oncology (2009)
  • Author(s): Hideaki Tahara, Marimo Sato, Magdalena, et al.
  • Journal Title: Journal of Translational Medicine 7 Pages: 45-70
• [Presentation] Induction of systemic and therapeutic antitumor immunity using dendritic cells genetically modified to express IL-23 (2010)
  • Author(s): Marimo Sato, Kimiyasu Yoneyama, Takafumi Nakamura, Hisako Katano, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪 リーガロイヤルホテル大阪
  • Year and Date: 2010-09-22
• [Presentation] Induction of systemic and therapeutic antitumor immunity using intratumoral injection of bone-marrow derived dendritic cells genetically modified to express IL-23 (2010)
  • Author(s): Marimo Sato, Kimiyasu Yoneyama, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第14回基盤的癌免疫研究会総会
  • Place of Presentation: 熊本 KKRホテル熊本
  • Year and Date: 2010-07-23
• [Presentation] Induction of antitumor effects using intratumoral injection of bone-marrow derived dendritic cells genetically modified to express IL-23 (2010)
  • Author(s): Marimo Sato, Kimiyasu Yoneyama, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第20回日本樹状細胞研究会総会
  • Place of Presentation: 新潟 朱鷺メッセ
  • Year and Date: 2010-06-19
• [Presentation] Induction of systemic and therapeutic antitumor immunity using dendritic cells genetically modified to express IL-23 (2010)
  • Author(s): Marimo Sato, Kimiyasu Yoneyama, Takafumi Nakamura, Hisako Katano, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
• [Presentation] Induction of systemic and therapeutic antitumor immunity using intratumoral injection of bone-marrow derived dendritic cells genetically modified to express IL-23 (2010)
  • Author(s): Marimo Sato, Kimiyasu Yoneyama, Takafumi Nakamura, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第14回基盤的癌免疫研究会総会
  • Place of Presentation: 熊本
• [Presentation] Induction of antitumor effects using intratumoral injection of bone-marrow derived dendritic cells genetically modified to express IL-23 (2010)
  • Author(s): Marimo Sato, Kimiyasu Yoneyama, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第20回日本樹状細胞研究会総会
  • Place of Presentation: 新潟
• [Presentation] IL-23併用投与によるDNAワクチンの臨床応用への検討 (2010)
  • Author(s): 米山公康、佐藤まりも、金本彰、伊藤精彦、田原秀晃
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
• [Presentation] Antigen-specific antitumor effects of DNA vaccine are significantly enhanced with systemic administration of IL-23 (2009)
  • Author(s): Kimiyasu Yoneyama, Marimo Sato, Masahisa Jinushi, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2009-12-04
• [Presentation] Antigen-specific antitumor effects of DNA vaccine are significantly enhanced with systemic administration of IL-23 (2009)
  • Author(s): Kimiyasu Yoneyama, Marimo Sato, Masahisa Jinushi, Yuko Kitagawa, Hideaki Tahara
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪
• [Presentation] Cancer vaccine against malignant melanoma using monocyte derived dendritic cells stimulated with OK-432 and PGE_2 (2009)
  • Author(s): Marimo Sato, Akira Kanamoto, Masahisa Jinushi, Hisako Katano, Kimiyasu Yoneyama, Akihiko Itoh, Hideaki Tahara
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] In situ antitumor immunotherapy with blockade of MFG-E8 and chemotherapy against solid and hematological tumors (2009)
  • Author(s): Masahisa Jinushi, Marimo Sato, Akira Kanamoto, Akihiko Itoh, Hideaki Tahara
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Clinical dendritic cell therapy using OK-432 and prostaglandin E_2 (Phase I study) (2009)
  • Author(s): Marimo Sato, Akira Kanamoto, Masahisa Jinushi, Hisako Katano, Kimiyasu Yoneyama, Akihiko Itoh, Hideaki Tahara
  • Organizer: 第19回日本樹状細胞研究会総会
  • Place of Presentation: 淡路
• [Presentation] Cancer immunotherapy using monocyte-derived DCs stimulated with OK-432 and prostaglandin E_2 pulsed with gp100 epitope peptide in malignant melanoma (2009)
  • Author(s): Marimo Sato, Akira Kanamoto, Masahisa Jinushi, Hisako Katano, Kimiyasu Yoneyama, Akihiko Itoh, Hideaki Tahara
  • Organizer: 第13回基盤的癌免疫研究会総会
  • Place of Presentation: 小倉
• [Book] がん免疫療法-実用化へのチャレンジ-(細胞療法におけるGMP化-樹状細胞を例として-)第20章 (2010)
  • Author(s): 佐藤まりも, 田原秀晃
• [Book] 細胞療法におけるGMP化-樹状細胞を例として-,『がん免疫法-実用化へのチャレンジ-』 (2010)
  • Author(s): 佐藤まりも, 田原秀晃
  • Publisher: シーエムシー出版
• [Book] 最新医学(サイトカインの腫瘍免疫における役割とその利用, 11月号64巻) (2009)
  • Author(s): 佐藤まりも、田原秀晃
  • Total Pages: 7
• [Remarks] ホームページ等
  • URL: http://www.ims.u-tokyo.ac.jp/sur+trans/sur+be/index.html