Anigiogenic therapy using anaerobic bacterial vector in ischemic cardiovascular disease.

• Project/Area Number: 21791246
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Shinshu University
• Principal Investigator: WADA Yuko Shinshu University, 医学部, 助教 (30419410)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 血管外科学 / DDS / 虚血性心血管疾患 / 血管新生療法 / 嫌気性菌 / 移植・再生医療 / ドラッグデリバリーシステム / 非ウイルスベクター

Research Abstract

We showed the specific accumulation of B.longum bacterium injected generally or locally to ischemic organ, and the disappearance of this bacterium from nonischemic organ using ischemic hind limb mouse model, and in cardiac infarction in miniature swine model.
We also showed that this anaerobic bacterial vector administration is generally and locally safe using mouse ischemic model. Anaerobic vector using B. longum bacterium may be an effective strategy for therapeutic neovascularization in patients with ischemic cardiovascular disease.