Role of muscarinic acetylcholine receptor in the development of transplant arteriosclerosis
| Project/Area Number |
21791247
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 移植後動脈硬化 / 慢性拒絶 / ムスカリン性ACh受容体 / 炎症細胞 / 遊走 |
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| Research Abstract |
We investigated the role of muscarinic acetylcholine receptor (mAChR) in the development of transplant arteriosclerosis. Mononuclear leukocytes were isolated from bone-marrow of mAChR deficient mice and wild-type (WT) mice. Cell migration was examined using a Boyden chamber system. Carbachol-induced leukocyte migration was significantly reduced in the cells harvested from mAChR-deficient mice. These results suggest that mAChR-mediated leukocyte migration may play an important role in the development of transplant arteriosclerosis.
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Report
(3 results)
Research Products
(3 results)
