Role of muscarinic acetylcholine receptor in the development of transplant arteriosclerosis

Research Project

Project/Area Number	21791247
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	MATSUMOTO Yuji 浜松医科大学, 医学部, 助教 (80397380)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	移植後動脈硬化 / 慢性拒絶 / ムスカリン性ACh受容体 / 炎症細胞 / 遊走
Research Abstract	We investigated the role of muscarinic acetylcholine receptor (mAChR) in the development of transplant arteriosclerosis. Mononuclear leukocytes were isolated from bone-marrow of mAChR deficient mice and wild-type (WT) mice. Cell migration was examined using a Boyden chamber system. Carbachol-induced leukocyte migration was significantly reduced in the cells harvested from mAChR-deficient mice. These results suggest that mAChR-mediated leukocyte migration may play an important role in the development of transplant arteriosclerosis.

Report

(3 results)