Induction of HER2-specific cellular immunity after trastuzumab therapy

• Project/Area Number: 21791248
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Mie University
• Principal Investigator: SAITO Kanako Mie University, 医学部附属病院, 助教 (90447871)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: HER2 / トラスツズマブ / CTL / HER2陽性CD8陽性T細胞 / HER2特異的CD8+T細胞

Research Abstract

We have investigated whether HER2-specific cellular immunity could be induced after trastuzumab therapy in HER2-positive breast cancer patients. We analyzed the induction of HER2 specific CD8+T cells before and after trastuzumab therapy by tetramer assay and ELISPOT assay. HER2p369 specific CD8+T cells after trastuzumab were detected in only HER2-positive metastatic breast cancer patients. We could not detect HER2-specific CD8+T cells in early breast cancer patients after trastuzumab.

Research Products

• [Journal Article] Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation. (2010)
  • Author(s): Torii M, Wang L, Saito K, Kato T.
  • Journal Title: Eur J Immunol Volume: 40 Pages: 787-96
  • Peer Reviewed
• [Journal Article] UV irradiation after immunization induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10. (2010)
  • Author(s): Wang L, Saito K, Kato T
  • Journal Title: Immunobiology Volume: 215 Pages: 124-32
  • Peer Reviewed
• [Journal Article] Elevated fibrin-related markers in patients with malignant diseases suspected of having thrombotic disorders. (2010)
  • Author(s): Nomura H, Wada H, Saito K, Nobori T.
  • Journal Title: Clin Appl Thromb Hemost Volume: 16 Pages: 266-72
  • Peer Reviewed
• [Journal Article] 処方の教室 : 乳癌 処方の読み方・とらえ方 (2009)
  • Author(s): 斎藤佳菜子, 他
  • Journal Title: レシピ 8 Pages: 16-22
• [Presentation] 術前化学療法後早期に中枢神経再発を来たした3例 (2010)
  • Author(s): 斎藤佳菜子
  • Organizer: 第18回日本乳癌学会学術総会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2010-06-25
• [Presentation] Clinical response of triple negative breast cancer to taxanes (2010)
  • Author(s): Kanako Saito
  • Organizer: 35^<th> ESMO congress 2010
  • Place of Presentation: ミラノ(イタリア)(publicationのみ)
• [Presentation] 乳癌術前化学療法によるHER2発現変化の検討 (2009)
  • Author(s): 斎藤佳菜子
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: バシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] Change of HER2 expression after neoajuvant trastuzumab and chemotherapy in primary breast cancer (2009)
  • Author(s): 斎藤佳菜子
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2009-10-02
• [Presentation] タモキシフェンでwithdrawal responseが得られた局所進行乳癌の1例 (2009)
  • Author(s): 斎藤佳菜子
  • Organizer: 第6回日本乳癌学会中部地方会
  • Place of Presentation: アクトシティ浜松コングレスセンター
  • Year and Date: 2009-09-12
• [Presentation] 脳転移を契機にHER2変化を確認できた再発乳癌の二例 (2009)
  • Author(s): 斎藤佳菜子
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: ホテル日航東京・ホテルグランパシフィックLE DAIBA
  • Year and Date: 2009-07-04
• [Book] 腫瘍薬学 (2010)
  • Author(s): 斎藤佳菜子, ら
  • Publisher: 南山堂