The attenuation of the diabetes-related functional impairment of bone marrow cells by antioxidant therapy
| Project/Area Number |
21791253
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KUBO Masayuki Yamaguchi University, 大学院・医学系研究科, 助教 (60420519)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 再生医療 / 骨髄細胞 / 血管新生 / 糖尿病 / 前駆細胞 / 酸化ストレス / 活性酸素 / 抗酸化 |
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| Research Abstract |
The implantation of autologous bone marrow cells did not improve clinical symptoms or regional perfusion of ischemia in some patients. It speculates that this poor angiogenic potency is related to the complications of diabetes mellitus. However, the precise mechanisms of diabetes-related impairment of bone marrow cells are not fully understood. This study shows that oxidative stress contributes to the diabetes-related functional impairment of bone marrow cells, which can be attenuated by antioxidant therapy.
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Report
(3 results)
Research Products
(12 results)
