| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Research Abstract |
The polycomb-group (PcG) proteins are critical determinant for the self-renewal capacity of the stem cells by transcriptional repression of developmental regulatory genes. In this study, to investigate the role of PcG protein in maintaining the self-renewal capability function in the hepatic stem cells, we examined the Ring1B target gens in hepatic stem cells by using the Ring1B conditional KO mice and DNA microarrays. We demonstrated that Ring1B repressed approximately 900 genes in hepatic stem cell. Ring1B target gene sets contained multiple genes related to cell cycle and apoptosis. Ring1B may regulate the self-renewal capacity of hepatic stem cells by suppressing cell cycle genes and apoptosis regulatory genes.
|
