• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Efficacy and safety of the immunotherapy using autoγδT lymphocyte for extrahepatic metastasis from hepatocellular carcinoma

Research Project

Project/Area Number 21791269
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research Institution公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2010)
The University of Tokyo (2009)

Principal Investigator

ARITA Junichi  公益財団法人がん研究会, 有明病院消化器外科, 医員 (20463838)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肝細胞癌 / 遠隔転移 / 免疫細胞療法 / γδT細胞
Research Abstract

An immunotherapy using autoγδT lymphocyte was conducted in patients with extrahepatic metises from hepatocellular carcinoma. In addition, an adjuvant therapy using combination of Gemcitabine and autoγδT lymphocyte immunotherapy was conducted for postoperative patients with intrahepatic cholangiocarcinoma, as a primary liver cancer like hepatocellular carcinoma. Three patients were enrolled in the former setting and 8 patients were enrolled in the latter setting. The safety of the therapy was confirmed, but the benefit in terms of progression-free survival was unclear. Because of the scarcity of the included patients, further enrollment of patients and follow-up will be necessary.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 2008

All Journal Article (15 results) (of which Peer Reviewed: 12 results) Presentation (19 results)

  • [Journal Article] Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expandedγδT cells : a phase I clinical study2011

    • Author(s)
      Sakamoto M, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Murayama T, Takamoto S, Matsushita H, Kakimi K
    • Journal Title

      J Immunother

      Volume: 34(2) Pages: 202-211

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] γδT-cell immunotherapy for lung cancer2011

    • Author(s)
      Yoshida Y, Nakajima J, Wada H, Kakimi K
    • Journal Title

      Surg Today

      Volume: 41(1) Pages: 606-611

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【膵癌診療と研究の最先端】術後補助療法としての自己γδT細胞免疫治療2011

    • Author(s)
      青木琢、垣見和宏、國土典宏
    • Journal Title

      胆と膵

      Volume: 32 Pages: 893-898

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 【外科医のための最新癌薬物療法】(III章)薬物療法あらたな展開免疫細胞治療2011

    • Author(s)
      野地秀一、瀬戸泰之、垣見和宏
    • Journal Title

      臨床外科

      Volume: 66 Pages: 276-84

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Expansion of human peripheral bloodγδT cells using zoledronate2011

    • Author(s)
      Kondo M, Izumi T, Fujieda N, Kondo A, Morishita T, Matsushita H, Kakimi K
    • Journal Title

      J Vis Exp

      Pages: 3182-3182

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] γδT-cell immunotherapy for lung cancer2011

    • Author(s)
      Yoshida Y, Nakajima J, Wada H, Kakimi K
    • Journal Title

      Surgery today

      Volume: 41(5) Issue: 5 Pages: 606-11

    • DOI

      10.1007/s00595-010-4478-7

    • NAID

      10029047060

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expansion of human peripheral bloodγδT cells using zoledronate2011

    • Author(s)
      Kondo M, Izumi T, Fujieda N, Kondo A, Morishita T, Matsushita H, Kakimi K
    • Journal Title

      Journal of visualized experiments : JoVE

      Volume: 55 Issue: 55 Pages: 3182-3182

    • DOI

      10.3791/3182

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adoptive Immunotherapy for Advanced Non-small CellLung Cancer Using Zoledronate-expanded gammadeltaTCells : A Phase I Clinical Study.2011

    • Author(s)
      Sakamoto M, Nakajima J, Murakawa T, et al.
    • Journal Title

      J Immunother

      Volume: 34 Pages: 202-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small cell lung cancer patients with autologous gammadelta T cells2010

    • Author(s)
      Nakajima J, Murakawa T, Fukami T, Goto S, Kaneko T, Yoshida Y, Takamoto S, Kakimi K
    • Journal Title

      Eur j cardiothorac Surg

      Volume: 37(5) Pages: 1191-1197

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells.2010

    • Author(s)
      Najima J, Murakawa T, Fukami T, et al.
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 37 Pages: 1191-1197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん特異的免疫療法の将来像2009

    • Author(s)
      國土典宏
    • Journal Title

      Cancer Review(日経メディカル)

      Volume: 8月号 Pages: 35-35

    • Related Report
      2011 Final Research Report
  • [Journal Article] Impact of culture medium on the expansion of T cells for immunotherapy2009

    • Author(s)
      Sato K, Kondo M, Sakuta K, Hosoi A, Noji S, Sugiura M, Yoshida Y, Kakimi K
    • Journal Title

      Cytotherapy

      Pages: 1-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of culture medium on the expansion of T cells for immunotherapy.2009

    • Author(s)
      Sato K
    • Journal Title

      Cytotherapy

      Volume: 11 Pages: 936-946

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells.2009

    • Author(s)
      Nakajima K
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 37 Pages: 1191-1197

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy2008

    • Author(s)
      Kondo M, Sakuta K, Noguchi A, Ariyoshi N, Sato K, Hosoi A, Nakajima J, Yoshida Y, Shiraishi K, Nakagawa K, Kakimi K
    • Journal Title

      Cytotherapy

      Volume: 10(8) Pages: 842-856

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Requirement for comon γ chain cytokines for adoptive transferred γδ T cell function and homeostasis in vivo2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Tamura N, Maekawa R
    • Organizer
      The 2nd Meeting of Asian Cellular Therapy Organizaiton 2011
    • Place of Presentation
      Miyazaki
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非小細胞肺癌に対するγδT細胞移入治療により末梢血中に蓄積されたγδT細胞の機能評価2011

    • Author(s)
      近藤篤, 藤枝奈緒, 森下岳晴, 近藤真, 泉謙道, 前川隆司, 松下博和, 垣見和宏
    • Organizer
      第20回日本癌病態治療研究会
    • Place of Presentation
      東京都
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 進行再発非小細胞肺癌に対するγδT細胞移入治療2011

    • Author(s)
      坂本未紀, 村山智紀, 村川知弘, 中島淳, 垣見和宏
    • Organizer
      第28回日本呼吸器外科学会総会
    • Place of Presentation
      大分県
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Requirement for common g chain family cytokines for adoptive transferred γδ T cell function and homeostasis in vivo2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Morishita T, R.Maekawa, Matsushita H
    • Organizer
      Immunology 2011 : 98th Annual Meeting The American Association of Immunologist 2011
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Requirement for common g chain family cytokines for adoptive transferredγδT cell function and homeostasis in vivo2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Morishita T, R. Maekawa, Matsushita H
    • Organizer
      Immunology 2011 : 98th Annual Meeting The American Association of Immunologist 2011
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Final Research Report
  • [Presentation] Requirement for comon・chain cytokines for adoptive transferredγδT cell function and homeostasis in vivo2011

    • Author(s)
      Kakimi K, Izumi T, Kondo M, Fujieda N, Kondo A, Tamura N, Maekawa R
    • Organizer
      The 2nd Meeting of Asian Cellular Therapy Organizaiton 2011
    • Place of Presentation
      Miyazaki
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞移入治療により末梢血中に蓄積されたγδT細胞の機能評価2011

    • Author(s)
      近藤篤,藤枝奈緒,森下岳晴,近藤真,泉謙道,前川隆司,松下博和,垣見和宏
    • Organizer
      第49回日本癌治療学会総会/学術集会
    • Place of Presentation
      愛知県
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 膵癌術後補助療法としての全身化学療法・自己γδT細胞免疫治療併用療法2011

    • Author(s)
      青木琢,垣見和宏,國土典宏
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己活性化γδT細胞による非小細胞肺癌免疫療法2010

    • Author(s)
      吉田幸弘, 村山智紀, 金子亨, 後藤重則, 村川知弘, 坂本未紀, 中島淳, 垣見和宏
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] がんに対するγδT細胞治療2010

    • Author(s)
      泉謙道、近藤真、垣見和宏
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] γδT細胞治療に用いるγδT細胞とその体内動態2010

    • Author(s)
      有吉直子, 野口敦崇, 近藤真, 泉謙道, 前川隆司, 垣見和宏
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      熊本市
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] がんに対する免疫細胞治療~がんワクチンと細胞移入治療~2010

    • Author(s)
      垣見和宏、中島淳、瀬戸泰之
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Adoptive gamma γδ T cell transfer for non-small cell lung cancer.2010

    • Author(s)
      Kazuhiro Kakimi, Tomohiro Murakawa, Takeshi Fukami, et al.
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      Washington, DC.
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] AdoptiveγδT cell transfer for non-small cell lung cancer2010

    • Author(s)
      Kakimi K, et al.
    • Organizer
      AACR 101^<st> Annual Meeting 2010
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] がんに対する免疫細胞治療~がんワクチンと細胞移入療法~2010

    • Author(s)
      垣見和宏, 他
    • Organizer
      第19回日本癌病態治療研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 自己活性化γδT細胞による非小細胞肺癌免疫療法2009

    • Author(s)
      吉田幸弘
    • Organizer
      第47回 日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell therapy(細胞療法)の新たなアプローチ ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療2009

    • Author(s)
      垣見和宏
    • Organizer
      第13回 日本がん免疫学会総会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] T細胞の増殖能と機能からみた細胞培養培地選択の重要性2009

    • Author(s)
      佐藤啓介
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      北九州市
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cell therapy(細胞療法)の新たなアプローチ:ゾレドロン酸を用いて培養したVγ9Vδ2T細胞による免疫細胞治療2009

    • Author(s)
      垣見和宏, 他
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州市
    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi