Efficacy and safety of the immunotherapy using autoγδT lymphocyte for extrahepatic metastasis from hepatocellular carcinoma
| Project/Area Number |
21791269
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | 公益財団法人がん研究会 (2011)
Japanese Foundation For Cancer Research (2010)
The University of Tokyo (2009) |
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Principal Investigator |
ARITA Junichi 公益財団法人がん研究会, 有明病院消化器外科, 医員 (20463838)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝細胞癌 / 遠隔転移 / 免疫細胞療法 / γδT細胞 |
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| Research Abstract |
An immunotherapy using autoγδT lymphocyte was conducted in patients with extrahepatic metises from hepatocellular carcinoma. In addition, an adjuvant therapy using combination of Gemcitabine and autoγδT lymphocyte immunotherapy was conducted for postoperative patients with intrahepatic cholangiocarcinoma, as a primary liver cancer like hepatocellular carcinoma. Three patients were enrolled in the former setting and 8 patients were enrolled in the latter setting. The safety of the therapy was confirmed, but the benefit in terms of progression-free survival was unclear. Because of the scarcity of the included patients, further enrollment of patients and follow-up will be necessary.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy2008
Author(s)
Kondo M, Sakuta K, Noguchi A, Ariyoshi N, Sato K, Hosoi A, Nakajima J, Yoshida Y, Shiraishi K, Nakagawa K, Kakimi K
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Journal Title
Cytotherapy
Volume: 10(8)
Pages: 842-856
Related Report
Peer Reviewed
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