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Analysis of new candidates for gastric cancer molecular markers

Research Project

Project/Area Number 21791270
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

NOZAKI Koji  東京大学, 医学部附属病院, 助教 (90302736)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords胃癌 / 細胞系統
Research Abstract

Gastric cancer remains the second leading cause of cancer-related death worldwide. HE4(WFDC2) is expressed in gastric metaplasia, intestinal metaplasia, and in the majority of intestinal type and signet ring gastric adenocarcinomas. Histamine and gastrin play important role in not only stimulated gastric acid secretion but also coordination of intramucosal growth and lineage differentiation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009

All Journal Article (10 results) (of which Peer Reviewed: 6 results) Presentation (17 results)

  • [Journal Article] 除菌後胃癌はなぜ発生するのか2011

    • Author(s)
      野崎浩二
    • Journal Title

      The GI Forefront

      Volume: 第6巻第2号 Pages: 127-131

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 食道・胃疾患.消化器外科学レビュー20112011

    • Author(s)
      野崎浩二、瀬戸泰之
    • Journal Title

      総合医学社

      Pages: 23-28

    • Related Report
      2011 Final Research Report
  • [Journal Article] 食道・胃疾患2011

    • Author(s)
      野崎浩二、瀬戸泰之
    • Journal Title

      消化器外科学レビュー2011

      Pages: 23-28

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 除菌後胃癌はなぜ発生するのか2011

    • Author(s)
      野崎浩二
    • Journal Title

      THE GI FOREFRONT Vol.6 No.2 JapanGAST Study Group

      Volume: 第6巻第2号 Pages: 127-131

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胃癌の最新知見-動物実験モデルからみたH. pylori感染と胃癌2010

    • Author(s)
      野崎浩二
    • Journal Title

      Pharma Medica

      Volume: 第28巻第8号 Pages: 35-40

    • Related Report
      2011 Final Research Report
  • [Journal Article] 胃癌の最新知見-実験モデルからみたH.pylori感染と胃癌2010

    • Author(s)
      野崎浩二
    • Journal Title

      Pharma Medica Vol.28 No.8

      Volume: 第28巻第8号 Pages: 35-40

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Altered gastric chief cell lineage differentiation in histamine-deficient mice2009

    • Author(s)
      Nozaki K, Weis V, Wang TC, Falus A, Goldenring JR
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

      Volume: 296

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice2009

    • Author(s)
      Aikou S, Fukushima Y, Ogawa M, Nozaki K, Saito T, Matsui T, Goldenring JR, Kaminishi M, Nomura S
    • Journal Title

      Dig Dis Sci

      Volume: 54 Pages: 1625-1635

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered gastric chief cell lineage differentiation in histamine-deficient mice2009

    • Author(s)
      Nozaki K, Weis V, Wang TC, Falus A, Goldenring JR.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol. 296

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alterations in gastric mucosal lineages before or after acute oxyntic atrophy in gastrin receptor and H2 histamine receptor-deficient mice2009

    • Author(s)
      Aikou S, Fukushima Y, Ogawa M, Nozaki K, Saito T, Matsui T, et al.
    • Journal Title

      Dig Dis Sci. 54

      Pages: 1625-1635

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Triple negative乳癌に対するBevacizumabの上乗せ効果に関する最近の臨床試験の動向2011

    • Author(s)
      野崎浩二、多田敬一郎、瀬戸泰之, ら
    • Organizer
      第32回 日本臨床薬理学会 臨床薬理42巻Page S242
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] HER2陽性進行胃癌におけるS-1/Cisplatin/Trastuzumab併用療法による臨床試験の策定2011

    • Author(s)
      野崎浩二、和田郁雄、瀬戸泰之, ら
    • Organizer
      第32回 日本臨床薬理学会 臨床薬理42巻Page S241
    • Place of Presentation
      アクトシティ浜松(静岡県)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 進行胃癌に対するTS-1/fractional CDDPを用いた術前補助化学療法(NAC)の第II相試験2011

    • Author(s)
      和田郁雄、野崎浩二、瀬戸泰之, ら
    • Organizer
      第66回 日本消化器外科学会総会Page 494
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 進行胃癌に対するTS-1/fractional CDDPを用いた術前補助化学療法(NAC)の第II相試験2011

    • Author(s)
      和田郁雄、野村幸世、神保敬一、三浦洋菜、北村聡子、森和彦、野崎浩二、上田哲也、清水伸幸、瀬戸泰之
    • Organizer
      第66回日本消化器外科学会総会
    • Related Report
      2011 Final Research Report
  • [Presentation] HER2陽性進行胃癌におけるS-1/Cisplatin/Trastuzumab併用療法による臨床試験の策定2011

    • Author(s)
      野崎浩二、和田郁雄、畑尾史彦、森和彦、清水伸幸、野村幸世、荒川義弘、齋藤延人、瀬戸泰之
    • Organizer
      第32回日本臨床薬理学会
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌予防の最前線-モデルから見た胃癌予防2010

    • Author(s)
      野崎浩二
    • Organizer
      がん予防学術大会2010
    • Place of Presentation
      北海道大学学術交流会館
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] ワークショップ除菌後胃癌はなぜ発生するのか-減少させることは可能か2010

    • Author(s)
      野崎浩二
    • Organizer
      第15回JapanGAST Study Group 2010
    • Place of Presentation
      京王プラザホテル札幌
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腹水細胞診陽性のみが非治癒因子のStage IV進行胃癌についての治療方針2010

    • Author(s)
      和田郁雄、野崎浩二、瀬戸泰之, 他
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 局所進行胃癌に対するS-1/weekly cisplatin術前化学療法2010

    • Author(s)
      野崎浩二、和田郁雄、野村幸世、清水伸幸、荒川義弘、門脇孝、瀬戸泰之
    • Organizer
      第31回日本臨床薬理学会
    • Related Report
      2011 Final Research Report
  • [Presentation] 腹水細胞診陽性のみが非治癒因子のStage IV進行胃癌についての治療方針2010

    • Author(s)
      和田郁雄、若松高太郎、神保敬一、清川貴志、西田正人、布部創也、野崎浩二、福田俊、畑尾史彦、安部仁、清水伸幸、野村幸世、瀬戸泰之
    • Organizer
      日本外科学会雑
    • Related Report
      2011 Final Research Report
  • [Presentation] 前癌病変としての萎縮性胃炎-壁細胞萎縮に伴う細胞系統の変化(消S1-1 シンポジウム1 胃癌対策としてのH.pylori 除菌)2009

    • Author(s)
      野崎浩二, 瀬戸泰之, Goldenring JR.
    • Organizer
      JDDW 2009/日本消化器病学会
    • Place of Presentation
      国立京都国際会館第1会場
    • Year and Date
      2009-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of gastric cell lineage differentiation an detection of novel secreted markers of gastric neoplastic process2009

    • Author(s)
      Nozaki K, Goldenring JR.
    • Organizer
      68th JCA 2009/日本癌学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] The AGA Foundation reception, "Faces of Philanthropy : A Quarter Century of Research Awards."2009

    • Author(s)
      Nozaki K, Goldenring JR.
    • Organizer
      DDW(Digestive Disease Week)2009 Chicago/AGA(American Gastroenterological Association)
    • Place of Presentation
      Intercontinental Chicago, USA
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] Faces of Philanthropy-A Quarter Century of Research Awards2009

    • Author(s)
      Nozaki K, Goldenring JR
    • Organizer
      The AGA Foundation reception, Digestive Disease Week(DDW/AGA) 2009 Chicago
    • Place of Presentation
      Intercontinental Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] A molecular signature of gastric pre neoplasia arising after acute parietal cell loss2009

    • Author(s)
      Nozaki K, Goldenring JR
    • Organizer
      68th JCA/日本癌学会2009,第68回日本癌学会総会記事Page 121
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Analysis of gastric cell lineage differenti ation and detection of novel secreted markers of gastric neoplastic process.網羅的解析による胃上皮化生および腸上皮化生モデル由来新規胃癌マーカー候補遺伝子群の同定2009

    • Author(s)
      Nozaki K, Goldenring JR
    • Organizer
      68th JCA/日本癌学会2009,第68回日本癌学会総会記事Page 97
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃癌対策としてのH. pylori除菌-前癌病変としての萎縮性胃炎-壁細胞萎縮に伴う細胞系統の変化2009

    • Author(s)
      野崎浩二、瀬戸泰之、Goldenring JR
    • Organizer
      JDDW 2009
    • Place of Presentation
      国立京都国際会館第1会場
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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