Relationship between cancer stem cells and bone marrow derived cells in esophageal and gastric cancer

• Project/Area Number: 21791274
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: University of Toyama
• Principal Investigator: OKUMURA Tomoyuki University of Toyama, 大学院・医学薬学研究部, 助教 (10533523)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 胃癌 / 食道癌 / 幹細胞 / 骨髄

Research Abstract

interaction between cancer stem cells and mesenchymal cells in esophageal and gastric cancer

Research Products

• [Journal Article] K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia. (2010)
  • Author(s): Okumura T, Ericksen RE, Takaishi S, Wang SS, Dubeykovskiy Z, Shibata W, Betz KS, Muthupalani S, Rogers AB, Fox JG, Rustgi AK, Wang TC.
  • Journal Title: Cancer Research 70(21) Pages: 8435-8445
  • Peer Reviewed
• [Journal Article] K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia. (2010)
  • Author(s): Okumura T, Ericksen RE, Takaishi S, Wang SS, Dubeykovskiy Z, Shibata W, Betz KS, Muthupalani S, Rogers AB, Fox JG, Rustgi AK, Wang TC.
  • Journal Title: Cancer Research Volume: 70(21) Pages: 8435-8445
  • Peer Reviewed
• [Journal Article] Identification of a bone marrow-derived mesenchymal progenitor cell subset that can contribute to the gastric epithelium. (2009)
  • Author(s): Okumura T, Wang SW, Takaishi S, Tu S, Ericksen R, Rustgi AK, Wang TC
  • Journal Title: Laboratory Investigation 89(12) Pages: 1410-1422
  • Peer Reviewed
• [Journal Article] Fibroblastic colony-forming unit bone marrow cells delay progression to gastric dysplasia in a helicobacter model of gastric tumorigenesis. (2009)
  • Author(s): Wang SS, Asfaha S, Okumura T, Betz KS, Muthupalani S, Rogers AB, Tu S, Takaishi S, Jin G, Yang X, Wu DC, Fox JG, Wang TC.
  • Journal Title: Stem Cells. 27(9) Pages: 2301-2311
  • Peer Reviewed
• [Journal Article] Identification of gastric cancer stem cells using the cell surface marker CD44 (2009)
  • Author(s): Takaishi S, Okumura T, Tu S, Wang SW, Shibata W, Vigneshwaran R, Gordon AK S, Shimada Y, Wang TC
  • Journal Title: Stem Cells. 27 Pages: 1006-1020
  • Peer Reviewed
• [Presentation] Identification of aldehyde dehydrogenase (ALDH) -1/CD44 double positive cells in gastric cancer. (2011)
  • Author(s): Tomoyuki Okumura, Yutaka Shimada, Soshi Osawa, Shinich Sekine, Ryota Hori, T Omura, Makoto Moriyama, Koshi Matsui, Isaku Yoshioka, Syojo Hojyo, Shigeaki Sawada, Toru Yoshida, Takuya Nagata Hideyuki Uotani, Junya Hukuoka, Kazuhiro Tsukada
  • Organizer: The 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-22
• [Presentation] 胃癌組織における幹細胞マーカーCD44およびALDH-1の発現 (2011)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、堀亮太、大村哲也、森山亮仁、松井恒志、吉岡伊作、澤田成朗、吉田徹、長田拓哉、魚谷英之、福岡順也、塚田一博
  • Organizer: 第83回日本胃癌学会総会
  • Place of Presentation: 青森県三沢市
  • Year and Date: 2011-03-05
• [Presentation] k19-krasマウス胃癌モデルにおけるDCAMKL-1およびLGR-5発現細胞の役割 (2011)
  • Author(s): 奥村知之、嶋田裕、Russell Ericksen、Sophie Wang、高石繁雄、Timothy Wang、塚田一博
  • Organizer: 第83回日本胃癌学会総会
  • Place of Presentation: 青森県三沢市
  • Year and Date: 2011-03-05
• [Presentation] 低親和性神経成長因子受容体(p75NTR)を標的とした食道癌治療の可能性 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、神山公希、堀亮太、澤田成明、吉田徹、長田拓哉、魚谷英之、塚田一博
  • Organizer: 第21回日本消化器癌発生学会総会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-18
• [Presentation] 低親和性神経成長因子受容体(p75NTR)を標的とした食道癌治療の可能性 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、神山公希、堀亮太、澤田成明、吉田徹、長田拓哉、魚谷英之、塚田一博
  • Organizer: 第21回日本消化器癌発生学会総会
  • Place of Presentation: 軽井沢プリンスホテル(長野)
  • Year and Date: 2010-11-18
• [Presentation] 胃癌におけるALDH-1の発現とその意義 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、澤田成朗、長田拓哉、福岡順也、塚田一博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 胃癌におけるALDH-1の発現とその意義 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、澤田成朗、長田拓哉、福岡順也、塚田一博
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-09-22
• [Presentation] Expression of miRNAs in p75NTR positive esophageal squamous cell carcinoma (2010)
  • Author(s): TomoyukiOkumura, Yutaka Shimada, Soshi Osawa, ShinichiSekine, Makoto Moriyama, Kazuhiro Tsukada
  • Organizer: The 12th World Congress of the International Society for Diseases of Esophagus
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2010-09-04
• [Presentation] p75NTR陽性食道扁平上皮癌細胞で発現しているmicro-RNAの探索 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、吉岡伊作、澤田成朗、吉田徹、長田拓哉、塚田一博
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関
  • Year and Date: 2010-07-14
• [Presentation] p75NTR陽性食道扁平上皮癌細胞で発現しているmicro-RNAの探索 (2010)
  • Author(s): 奥村知之、嶋田裕、大澤宗士、関根慎一、吉岡伊作、澤田成朗、吉田徹、長田拓哉、塚田一博
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関グランドホテル(山口)
  • Year and Date: 2010-07-14
• [Presentation] 胃発癌における組織幹細胞および骨髄由来幹細胞の役割 (2009)
  • Author(s): 奥村知之
  • Organizer: 第20回日本に消化器癌発生学会
  • Place of Presentation: オリェンタルホテル広島(広島県)
  • Year and Date: 2009-11-26
• [Presentation] 神経成長因子受容体を分子標的とした食道小細胞癌補助療法の可能性 (2009)
  • Author(s): 奥村知之
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-01