Clarification of a mechanism of metastasis in hepatocellular carcinoma based on hepatitis C virus infection by analysis of expression of Metastatic Tumor Antigen(MTA-1)

• Project/Area Number: 21791277
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: University of Yamanashi
• Principal Investigator: ASAKAWA Masami 山梨大学, 大学院・医学工学総合研究部, 医学研究員 (10456460)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肝細胞癌 / MTA-1 / 肝内転移 / HIF-1α / Rac / 無再発生存期間 / CD31 / α-SMA / MCSF / CD68マクロファージ / CD163マクロファージ / VEGF / EGF / 免疫染色 / 血行性肝内転移 / mRNA / MTA1 / 多臓器転移 / 肝転移 / C型肝炎 / 予後

Research Abstract

VEGF which is induced by MAT-1 through HIF-1αwas highly expressed in the peritumor lesion where expression of MAT-1 was not found. So, MAT-1 has no connection with intrahepatic metastasis of hepatocellular carcinoma based on hepatitis C virus infection. Cytokines produced from the liver macrophage participate in intrahepatic metastasis of hepatocellular carcinoma because of the findings of highly invasion of liver macrophage and high expression of TGFβin the lesion where VGF is expressed

Research Products

• [Journal Article] Imag ing study of early hepatocellular car cinoma (2011)
  • Author(s): Sano K, Ichikawa T, Motosugi U, Sou H, Muhi AM, Matsuda M, Nakano M, Sakamo to M, Nakazawa T, Asakawa M, Fujii H, Kitamura T, Enomoto N, Araki T
  • Journal Title: usefulness of gadoxetic acid-enhanced MR imaging Volume: 261(3) Pages: 834-44
  • Peer Reviewed
• [Journal Article] Double-dose gadoxetic Acid-enhanced magnetic resonance imaging in patients with chronic liver disease (2011)
  • Author(s): Motosugi U, Ichikawa T, Sano K, Sou H, Onohara K, Muhi A, Kitamura T, Amemiya F, Enomoto N, Matsuda M, Asakawa M, Fujii H, Araki T
  • Journal Title: Invest Radiol Volume: 46(2) Pages: 141-5
  • Peer Reviewed
• [Journal Article] Lens culinaris agglutinin-reacti ve fraction of AFP is a useful progno stic biomarker for survival after rep eat hepatic resection for HCC (2011)
  • Author(s): Matsuda M, Asakawa M, Amemiya H, Fuji i H
  • Journal Title: J Gas troenterol Hepatol Volume: 26(4) Pages: 731-8
  • Peer Reviewed
• [Journal Article] Imaging study of early hepatocellular carcinoma : usefulness of gadoxeticacid-enhanced MR imaging (2011)
  • Author(s): Sano Katsuhiro
  • Journal Title: Radiology Volume: 261(3) Pages: 834-844
  • Peer Reviewed
• [Journal Article] Lens culinaris agglutinin-reactive fraction of AFP is a useful prognostic biomarker for survival after repeat hepatic resection for HCC (2011)
  • Author(s): Masanori Matsuda
  • Journal Title: J Gastroenterol Hepatol Volume: 26(4) Issue: 4 Pages: 731-738
  • DOI: 10.1111/j.1440-1746.2010.06532.x
  • Peer Reviewed
• [Journal Article] Double-dose gadoxetic Acid-enhanced magnetic resonance imaging in patients with chronic liver disease (2011)
  • Author(s): Motosugi Utaro
  • Journal Title: Invest Radiol Volume: 46(2) Pages: 141-145
  • Peer Reviewed
• [Journal Article] Lens culinaris agglutinin-reactive fraction of AFP is a useful prognostic biomarker for survival after repeat hepatic resection for HCC. (2011)
  • Author(s): Masanori Matsuda
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 1440-1746
  • Peer Reviewed
• [Journal Article] Double-dose gadoxetic Acid-enhanced magnetic resonance imaging in patients with chronic liver disease. (2011)
  • Author(s): Utaro Motosugi
  • Journal Title: Invest Radiol. Volume: 46 Pages: 141-145
  • Peer Reviewed
• [Journal Article] Complete remission of multiple recurrent hepatocellular carcinomas by oral administration of enteric-coated tegafur/uracil in a patient with huge hepatocellular carcinoma extending to the inferior vena cava after hepatic resection : analysis of mRNA expression of fluoropyrimidine metabolism enzymes in the primary tumor (2009)
  • Author(s): Matsuda M, Shiba S, Asakawa M, Kono H, Fujii H
  • Journal Title: Int J Clin Oncol Volume: 14(3) Pages: 245-8
  • NAID: 10025148272
  • Peer Reviewed
• [Presentation] 肝細胞癌切除後10年以上無発症症例の検討からみえてきた (2011)
  • Author(s): 松田政徳, 他
  • Organizer: 長期生存に寄与する因子, JDDW2011
  • Place of Presentation: 福岡県
  • Year and Date: 2011-10-20
• [Presentation] 長期生存を目指した肝細胞癌切除後再発への治療戦略とその成績 (2010)
  • Author(s): 松田政徳, 他
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 山口県
  • Year and Date: 2010-07-14
• [Presentation] 長期予後改善をめざした肝細胞癌治療-切除後再発の治療戦略とその成績 (2010)
  • Author(s): 松田政徳, 他
  • Organizer: 第46回日本肝臓研究会
  • Year and Date: 2010-07-08