| Project/Area Number |
21791280
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
TOIYAMA Yuji Mie University, 大学院・医学系研究科, 助教 (00422824)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 大腸癌 / 予後因子 / サイトカイン / ケモカイン / 遠隔転移 / 血清予後因子 / 上皮間葉移行 / 予後マーカー |
|---|
| Research Abstract |
The aim of this study is to identify novel and reliable serum markers related to the prognosis of colorectal cancer (CRC) patients and to assess the association between selected markers and clinical outcome. We identified HGF and several chemokines as novel prognostic markers in CRC patients and they significantly correlated with vascular metastasis, such as liver or lung metastasis. Serum HGF predicts poor prognosis patients in colorectal cancer with curative intent and that high expression of several serum chemokines are induced by secretion from target organs, such as liver or lung, in a paracrine fashion and showed the revelation of the metastatic destination for CRC and allows the progression of cancer cells in these metastatic sites.
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