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Approaches to regenerate pancreatic function by converting liver blood flow and transferring specific gene

Research Project

Project/Area Number 21791282
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

FUJINO Kazunori  滋賀医科大学, 医学部, 助教 (70402716)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膵再生 / 遺伝子治療 / ファージベクター
Research Abstract

Although we found the both anti-insulin and anti-trypsin positive cells in the liver that interrupted portal blood flow by the immunohistochemical study, that immature cell cluster didn' t have any secretary granules. In this study, we attempted to introduce differentiation enhancing factor to the cluster by gene therapy, and generate pancreatic endocrine and exocrine cells. Although we try to make phage vector to deliver differentiation enhancing factor to the cluster for these research period, we couldn' t find adequate amount vector-transfected cells in both the liver and bile duct. We will continue to make vector for it in the future.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] Homing of the bone marrow-derived interstitial cells of Cajal is decreased in diabetic mouse intestine2011

    • Author(s)
      Li Y, Kojima H, Fujino K, Matsumura K, Katagi M, Urabe H, Chan L, Eguchi Y, Zhao L, Kimura H.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: Vol.26, no.6 Pages: 1072-1078

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin family of peptides and gut motility2011

    • Author(s)
      Asakawa A, Ataka K, Fujino K, Chen CY, Kato I, Fujimiya M, Inui A.
    • Journal Title

      J Gastroenterol Hepatol, suppl

      Volume: no.3 Pages: 73-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Homing of the bone marrow-derived interstitial cells of Cajal is decreased in diabetic mouse intestine2011

    • Author(s)
      Li Y
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 26 Pages: 1072-1078

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parathyroid hormone-related protein has an anorexigenic activity via activation of hypothalamic urocortins 2 and 32010

    • Author(s)
      Asakawa A, Fujimiya M, Niijima A, Fujino K, Kodama N, Sato Y, Kato I, Nanba H, Laviano A, Meguid MM, Inui A.
    • Journal Title

      Psychoneuroendocrinology

      Volume: Vol.35, No.8 Pages: 1178-1186

    • Related Report
      2011 Final Research Report
    • Peer Reviewed

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Published: 2009-04-01   Modified: 2016-04-21  

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