| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To investigate the origin of hepatic fibroblasts, we utilized the transgenic mice which express GFP under collagen type 1 promoter (Coll GFP mice). In fibrotic livers, several kinds of collagen expressing cells were found in addition to the hepatic stellate cells, which are believed to be the principal source of hepatic fibroblasts. It was noteworthy that there were small and round-shaped collagen-expressing cells with distinct morphology from hepatic stellate cells. Flow cytometry also demonstrated a GFP(+) cell fraction other than hepatic stellate cells. Although it has not been fully characterized yet, it could be a novel fibrogenic cells in the liver.
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