Development of a novel treatment strategy for liver fibrosis by exploring the origin of fibroblast
Project/Area Number |
21791284
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Digestive surgery
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Research Institution | Kyoto University |
Principal Investigator |
TAURA Kojiro Kyoto University, 医学研究科, 助教 (80378629)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 肝線維化 / 線維芽細胞 / 星細胞 / 幹細胞 / 肝卵形細胞 / 肝星細胞 |
Research Abstract |
To investigate the origin of hepatic fibroblasts, we utilized the transgenic mice which express GFP under collagen type 1 promoter (Coll GFP mice). In fibrotic livers, several kinds of collagen expressing cells were found in addition to the hepatic stellate cells, which are believed to be the principal source of hepatic fibroblasts. It was noteworthy that there were small and round-shaped collagen-expressing cells with distinct morphology from hepatic stellate cells. Flow cytometry also demonstrated a GFP(+) cell fraction other than hepatic stellate cells. Although it has not been fully characterized yet, it could be a novel fibrogenic cells in the liver.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] 診断・治療支援の部2010
Author(s)
波多野悦朗, 中村公治郎, 田浦康二朗, 上本伸二, 4人中3番目
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Journal Title
転移性肝がんにおける術中造影超音波検査の意義INNERVISION 25巻
Pages: 64-67
Related Report
Peer Reviewed
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