Development of the novel molecular targeted therapy against hepatocellular carcinoma invasion and metastasis

• Project/Area Number: 21791288
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: KOBAYASHI Tsuyoshi 広島大学, 病院, 病院助教 (50528007)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 癌 / 遺伝子 / 蛋白質 / 細胞・組織 / 外科

Research Abstract

The aim of this study was to develop the novel molecular targeted therapy against hepatocellular carcinoma invasion and metastasis. Although we were not able to clarify the clinical significance of expression of h-prune in hepatocellular carcinoma, we elucidated that h-prune frequently expressed in thyroid cancers and had an essential role in anaplastic thyroid cancer cell invasion and metastasis.

Research Products

• [Journal Article] No impact of perioperative blood transfusion on recurrence of hepatocellular carcinoma after hepatectomy (2012)
  • Author(s): Kuroda S, Tashiro H, Kobayashi T, et al
  • Journal Title: World journal of surgery Volume: 36 Pages: 651-8
  • Peer Reviewed
• [Journal Article] Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver (2012)
  • Author(s): Kuroda S, Tashiro H, Igarashi Y, Tanimoto Y, Nambu J, Oshita A, Kobayashi T, Amano H, Tanaka Y, Ohdan H
  • Journal Title: Journal of Hepatology Volume: 56 Issue: 1 Pages: 146-152
  • DOI: 10.1016/j.jhep.2011.04.029
  • Peer Reviewed
• [Journal Article] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection (2012)
  • Author(s): Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H
  • Journal Title: Ann Surg Oncol Volume: 19 Issue: 2 Pages: 418-425
  • DOI: 10.1245/s10434-011-1866-1
  • Peer Reviewed
• [Journal Article] 甲状腺未分化癌の浸潤転移機構におけるh-pruneの役割 (2011)
  • Author(s): 楠部潤子, 小林剛, 田代裕尊, 他
  • Journal Title: 内分泌外科 Volume: 28 Pages: 232-237
  • NAID: 10030391894
• [Journal Article] Selection criteria for hepatectomy in patients with hepatocellular carcinoma classified as Child-Pugh class B (2011)
  • Author(s): Kuroda S, Tashiro H, Kobayashi T, et al
  • Journal Title: World J Surg Volume: 35 Pages: 834-41
  • Peer Reviewed
• [Journal Article] Factors relating to tumor do not influence the prognosis of solitary hepatocellular carcinoma after partial hepatectomy (2011)
  • Author(s): Kobayashi T, Itamoto T, Tashiro H, Kuroda S, Tazawa H, Tanimoto Y, Ushitora Y, Oshita A, Amano H, Ohdan H
  • Journal Title: J HBP science Volume: 18 Issue: 5 Pages: 689-699
  • DOI: 10.1007/s00534-011-0379-4
  • Peer Reviewed
• [Journal Article] 肝癌再発予防 (2011)
  • Author(s): 小林剛, 大段秀樹.
  • Journal Title: 外科治療 Volume: 105 Pages: 467-474
• [Journal Article] A huge metastatic liver tumor from leiomyosarcoma of the inferior vena cava : report of a case (2011)
  • Author(s): Hashimoto M, Kobayashi T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Aikata H, Chayama K, Fujii M, Arihiro K, Ohdan H
  • Journal Title: Surg Today (Epub 30 Nov.) Volume: (Epub) Issue: 5 Pages: 505-508
  • DOI: 10.1007/s00595-011-0070-z
  • NAID: 10030621850
  • Peer Reviewed
• [Journal Article] Treatment strategy for early hepatocellular carcinomas : comparison of radiofrequency ablation with or without transcatheter arterial chemoembolization and surgical resection (2011)
  • Author(s): Tashiro H, Aikata H, Waki K, Amano H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Chayama K, Asahara T, Ohdan H
  • Journal Title: J Surg Oncol Volume: 104 Issue: 1 Pages: 3-9
  • DOI: 10.1002/jso.21745
  • Peer Reviewed
• [Journal Article] Significance of platelet count in the outcomes of hepatectomized patients with hepatocellular carcinoma exceeding the Milan criteria (2011)
  • Author(s): Amano H, Tashiro H, Oshita A, Kobayashi T, Tanimoto Y, Kuroda S, Tazawa H, Itamoto T, Asahara T, Ohdan H
  • Journal Title: J Gastrointest Surg Volume: 15 Issue: 7 Pages: 1173-1181
  • DOI: 10.1007/s11605-011-1538-2
  • Peer Reviewed
• [Journal Article] Splenectomy in chronic hepatic disorders : portal vein thrombosis and improvement of liver function (2011)
  • Author(s): Ushitora Y, Tashiro H, Takahashi S, Amano H, Oshita A, Kobayshi T, Chayama K, Ohdan H
  • Journal Title: Digestive Surgery Volume: 28 Issue: 1 Pages: 9-14
  • DOI: 10.1159/000321886
  • Peer Reviewed
• [Journal Article] Selection criteria for hepatectomy in patients with hepatocellular carcinoma classified as child-pugh class B. (2011)
  • Author(s): Kuroda S, Tashiro H, Kobayashi T, Oshita A, Amano H, Ohdan H.
  • Journal Title: World Journal of Surgery Volume: 35 Pages: 834-841
  • Peer Reviewed
• [Journal Article] Splenectomy in chronic hepatic disorders : portal vein thrombosis and improvement of liver function. (2011)
  • Author(s): Ushitora Y, Tashiro H, Takahashi S, Amano H, Oshita A, Kobayashi T, Chayama K, Ohdan H.
  • Journal Title: Digestive Surgery Volume: 28 Pages: 9-14
  • Peer Reviewed
• [Journal Article] Tumor-related factors do not influence the prognosis of solitary hepatocellular carcinoma after partial hepatectomy. (2011)
  • Author(s): Kobayashi T, Itamoto T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Ohdan H.
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences Volume: (in press)
  • NAID: 10029688478
  • Peer Reviewed
• [Journal Article] Suppression of hepatocellular carcinoma recurrence after rat liver transplantation by FTY720, a sphingosine-1-phosphate analog. (2009)
  • Author(s): Ushitora Y, Tashiro H, Ogawa T, Tanimoto Y, Kuroda S, Kobayashi T, Miyata Y, Itamoto, T, Asahara T, Ohdan H
  • Journal Title: Transplantation 88 Pages: 980-986
  • Peer Reviewed
• [Journal Article] Hepatectomy for hepatocellular carcinoma in elderly patients aged 75 years or more. (2009)
  • Author(s): Oishi K, Itamoto T, Kobayahi T, Osuhita A, Amano H, Ohdan H, Tashiro H, Asahara T
  • Journal Title: Journal of gastrointestional surgery 13 Pages: 695-701
  • Peer Reviewed
• [Presentation] 甲状腺未分化癌の浸潤転移機構におけるh-pruneの役割 (2011)
  • Author(s): 楠部潤子, 小林剛, 田代裕尊, 杉野圭三, 嶋本文雄, 菊池章, 大段秀樹
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] 高度脈管侵襲を伴う肝細胞癌に対する肝切除成績 (2011)
  • Author(s): 小林剛、田代裕尊, 天野尋暢, 大下彰彦, 谷本新学, 田澤宏文, 黒田慎太郎, 楠部潤子, 藤國宣明, 相方浩, 大段秀樹.
  • Organizer: 第23回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-10
• [Presentation] 世界に発信する内分泌外科の臨床と基礎研究甲状腺未分化癌の浸潤転移機構におけるh-pruneの役割 (2011)
  • Author(s): 楠部潤子, 小林剛, 田代裕尊, 杉野圭三, 嶋本文雄, 大段秀樹
  • Organizer: 日本内分泌外科学会総会
  • Place of Presentation: 東京
• [Presentation] 肝細胞癌に対する肝中央二区域切除 (2010)
  • Author(s): 小林剛
  • Organizer: 第22回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-27
• [Presentation] 肝細胞癌脈管侵襲予測因子の解析 (2009)
  • Author(s): 小林剛
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: リーガロイヤルホテル(大阪)
  • Year and Date: 2009-07-16
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/home2ge/research_liver.html
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/home2ge/index.html
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/home2ge/index.html
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/home2ge/index.html