Mechanism of recurrence in hepatocel lular carcinoma after livertransplantation
| Project/Area Number |
21791292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IMURA Satoru The University of Tokushima, 病院, 助教 (90380021)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Mitsuo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10216070)
MORINE Yuji 徳島大学, 病院, 助教 (60398021)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 肝臓外科学 / 肝細胞癌 / 転移再発 / インターフェロン / 肝移植 / 微小転移 / 肝癌 / 肝移植後再発 / micrometastasis / 浸潤・転移 / 臓器親和性 |
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| Research Abstract |
The aim of this study was to clarify the mechanism of liver metastasis after liver transplantation. Splenic injection model was used as micrometastasis setting via portal vein. Macroscopic metastasis was observed in all mice, but IFN administration significantly decreased number of liver metastasis (19.3 versus 6.0, p<0.05). Microvessel density was quantified using CD34 immunostaining and IFN significantly suppressed angiogenesis compared with control. Expression of adhesion molecules such as VCAM and ICAM did not correlate with IFN treatment.
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Report
(3 results)
Research Products
(28 results)
