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The analysis of senescence as a cancer suppressing mechanism in pancreatic carcinogenesis and its introduction to the diagnostic and therapeutic strategy

Research Project

Project/Area Number 21791294
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

MIYASAKA Yoshihiro  Kyushu University, 医学研究院 (40507795)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords膵臓外科学 / 膵癌 / セネセンス
Research Abstract

We analyzed the expression levels of senescence associated markers, including senescence-associated β-galactosidase (SA-β-gal), senescence-associated heterochromatin foci (SAHF), p16INK4A, and p15INK4B, in normal pancreas, pancreatic cancer, and intraductal papillary mucinous neoplasm (IPMN) tissues. As the result, we found that the percentage of positive cases was lowest in normal pancreas and it reached a peak in IPMN with low-grade dysplasia. Furthermore, it showed significant decreasing trends in the transition from IPMN with low-grade dysplasia to IPMN with an associated invasive carcinoma. These results indicated that senescence is induced in the early stage of IPMN and gradually attenuated according to the progression. It is suggested that senescence plays a role in preventing malignant progression of IPMN. Additionally, we established the reliable methods to quantify the expression levels of microRNA and mRNA in pancreatic juice and FNA cytological samples. These methods are potent strategy to perform individualized therapy in preoperative and unresectable cases.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] High EGFR mRNA expression is a prognostic factor for reduced survival in pancreatic cancer after gemcitabine-based adjuvant chemotherapy2011

    • Author(s)
      Fujita H, et al.
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 629-641

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD44v6 expression in intraductal papillary mucinous neoplasms of the pancreas2010

    • Author(s)
      Miyasaka Y, et al.
    • Journal Title

      Pancreas

      Volume: 39 Pages: 31-35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy2010

    • Author(s)
      Fujita H, et al.
    • Journal Title

      Neoplasia

      Volume: 12 Pages: 807-817

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prognostic value of EGFR mRNA expression levels in resected pancreatic adenocarcinoma2010

    • Author(s)
      Hayato Fujita
    • Organizer
      第69回 日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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